Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure (BP) in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats (SHR) with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone (55-65 dB,played by the five elements of music rhythm instrument,a kind of physio-therapy regimen music played by Shen Wu) once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin Ⅱ (Ang-Ⅱ),thromboxane B2(TXB2),endothelin-1 (ET-1),calcitonin gene-related peptide (cGRP),norepinephrine (NE),cortisol(CORT),and 5-hydroxytryptamine (5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species (ROS).

Qian Zhou;Yufeng Chen;Sitong Zhang;Pei Yang;Tian Wang;Jianxin Chen;Huihui Zhao;Wei Wang;Xueling Ma

School of Nursing,Beijing University of Chinese Medicine,Beijing 102488,China;School of Nursing and Health,Zhengzhou University,Zhengzhou 450000,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China

中医科学杂志（英文）

[1]Qian Zhou;Yufeng Chen;Sitong Zhang;Pei Yang;Tian Wang;Jianxin Chen;Huihui Zhao;Wei Wang;Xueling Ma-.The effect of continuous Jue tone intervention on blood pressure and vasoactive substances in hypertensive rats with a liver-fire hyperactivity pattern)[J].中医科学杂志（英文）,2022(01):40-46

Jue,melodious,cGRP

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