典型文献
Orientin and vitexin attenuate lipopolysaccharide-induced inflammatory responses in RAW264.7 cells: a molecular docking study, biochemical characterization, and mechanism analysis
文献摘要：
Plant flavonoids have received considerable attention for their health benefits. However, structure-activity relationships between flavonoids such as orientin and vitexin with similar structures are rarely reported. In the present study, molecular docking study suggested that orientin and vitexin suppressed inflammatory responses through the modulation of the mitogen-activated protein kinase (MAPK) signaling pathway. Moreover, RAW264.7 cells with lipopolysaccharide-induced inflammation were used to evaluate the anti-inflammatory activities of orientin and vitexin, based on the inflammation-related cytokines production, quantitative real-time reverse transcription PCR, and western blotting analysis. As a result, orientin or vitexin attenuated inflammatory responses through modulation of the MAPK/NF-κB signaling pathway by suppressing NF-κB translocation.
文献关键词：
中图分类号：
作者姓名：
Yue Yu;Fusheng Pei;Zhanming Li
作者机构：
School of Grain Science and Technology,Jiangsu University of Science and Technology,Zhenjiang 212004,China
文献出处：
引用格式：
[1]Yue Yu;Fusheng Pei;Zhanming Li-.Orientin and vitexin attenuate lipopolysaccharide-induced inflammatory responses in RAW264.7 cells: a molecular docking study, biochemical characterization, and mechanism analysis)[J].食品科学与人类健康（英文）,2022(05):1273-1281
A类：
Orientin,orientin
B类：
vitexin,lipopolysaccharide,induced,inflammatory,responses,RAW264,cells,molecular,docking,study,biochemical,characterization,mechanism,analysis,Plant,flavonoids,have,received,considerable,attention,their,health,benefits,However,activity,relationships,between,such,similar,structures,rarely,reported,In,present,suggested,that,suppressed,through,modulation,mitogen,activated,protein,kinase,MAPK,signaling,pathway,Moreover,inflammation,were,used,evaluate,activities,related,cytokines,production,quantitative,real,reverse,transcription,western,blotting,result,attenuated,by,suppressing,translocation
AB值：
0.522946
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
