典型文献
Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs
文献摘要：
Recently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0％ (HF group), 1％, 3％, 5％, 8％ or 12％ (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R2 =–0.990), subcutaneous adipose accumulation (R2 =–0.930), serum triglyceride elevation (R2 =–0.879), acetate (R2 = 0.955) and propionate concentration reduction (R2 = 0.985) were suppressed by pectin from 1％ to 12％, indicating dose response to pectin consumption. Moreover, abundance of obesity-related bacteria Coriobacteriaceae, and pectin-degradating bacteria, Faecalibaculum, Ruminococcus were signifi cantly increased with pectin dosage increased, and the R2 were 0.936, 0.963 and 0.937, respectively. Besides, attenuations for colonic injury and liver steatosis were observed after adding 5％ and 8％ pectin, respectively. This study confi rmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production.
文献关键词：
中图分类号：
作者姓名：
Yuanyuan Zhao;Jinfeng Bi;Jianyong Yi;Jian Peng;Qiancheng Ma
作者机构：
Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences(CAAS)/Key Laboratory of Agro-Products Processing,Ministry of Agriculture and Rural Affairs,Beijing 100193,China;Sericultural and Agri-Food Research Institute,Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Agricultural Products Processing,Guangzhou 510610,China;School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China
文献出处：
引用格式：
[1]Yuanyuan Zhao;Jinfeng Bi;Jianyong Yi;Jian Peng;Qiancheng Ma-.Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs)[J].食品科学与人类健康（英文）,2022(01):143-154
A类：
degradating,rmed
B类：
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AB值：
0.605261
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