典型文献
3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration
文献摘要：
Physical forces,such as magnetic and mechanical stimulation,are known to play a significant role in the regulation of cell response.In the present study,a biomimetic regeneration patch was fabricated using E-jet 3D printing,which integrates mechanical and magnetic stimulation in a biocompatible"one-pot reaction"strategy when combined with a static magnetic field(SMF).The magneto-based therapeutic regeneration patch induced myoblasts to form aligned and multinucleated myotubes,regulated the expression of myogenic-related genes,and activated the p38α mitogen-activated protein kinase pathway via the initiation of myogenic differentiation.To validate the efficiency of the proposed strategy,the regeneration patch was implanted into mice and exposed to a suitable SMF,which resulted in significantly enhanced in vivo skeletal muscle regeneration.The findings demonstrated that appropriate external physical stimulation provides a suitable biophysical microenvironment that is conducive to tissue regeneration.The method used in the present study represents a promising technique to induce the regeneration of damaged skeletal muscle tissue.
文献关键词：
中图分类号：
作者姓名：
Xiaocheng Wang;Ruibo Zhao;Jian Wang;Xinghuan Li;Lijuan Jin;Wenyu Liu;Lifang Yang;Yonghua Zhu;Zhikai Tan
作者机构：
College of Biology,Hunan University,Changsha 410082,China;Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008,China;Key Laboratory of Carcinogenesis and Cancer Invasions of Ministry of Education, School of Basic Medicine Science, Cancer Research Institute, Central South University, Changsha 410008, China
文献出处：
引用格式：
[1]Xiaocheng Wang;Ruibo Zhao;Jian Wang;Xinghuan Li;Lijuan Jin;Wenyu Liu;Lifang Yang;Yonghua Zhu;Zhikai Tan-.3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration)[J].生物设计与制造（英文）,2022(02):249-264
A类：
multinucleated
B类：
printed,tissue,repair,patch,combining,mechanical,support,magnetism,controlled,skeletal,muscle,regeneration,Physical,forces,such,magnetic,stimulation,are,known,play,role,regulation,cell,response,In,study,biomimetic,was,fabricated,using,jet,printing,which,integrates,biocompatible,one,pot,reaction,strategy,when,combined,static,field,SMF,magneto,therapeutic,induced,myoblasts,form,aligned,myotubes,regulated,expression,myogenic,related,genes,activated,p38,mitogen,protein,kinase,pathway,via,initiation,differentiation,To,validate,efficiency,proposed,implanted,into,mice,exposed,suitable,resulted,significantly,enhanced,vivo,findings,demonstrated,that,appropriate,external,provides,biophysical,microenvironment,conducive,method,used,represents,promising,technique,damaged
AB值：
0.62184
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
