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典型文献
异基因造血干细胞移植患者体内环孢素A和伏立康唑的相互作用
文献摘要:
目的 分析异基因造血干细胞移植(Allo-HSCT)患者,静脉滴注伏立康唑(VRZ)与环孢素A(CsA)后的药物相互作用(DDI),为临床精准药物治疗提供依据.方法 进行一项患者自身对照研究,根据纳入排除标准,收集2019年1月—12月在某院进行Allo-HSCT的患者,采用LC-MS/MS法测定术前CsA给药后3~5 d的血药浓度2次,测定术后VRZ给药5~7 d后,CsA和VRZ同一时间的血药浓度2次,分别求其给药前后CsA、VRZ血药浓度的平均值.使用SPSS 20.0对VRZ给药前后CsA标准化血药浓度(C/D)的差异及VRZ血药浓度对CsA的C/D变化进行统计分析.结果 共纳入Allo-HSCT患者15例,用Wilcoxon符号秩和检验比较给药VRZ前后,CsA的C/D中位数变化,有显著性差异(P<0.001).对VRZ血药浓度与CsA的C/D比值增幅进行Spearman相关性分析,两者无显著相关性(ρ=?0.273,P=0.32).结论 CsA与VRZ之间存在明显的药物相互作用(DDI),VRZ使CsA血药浓度显著升高,但VRZ与CsA之间的DDI程度大小与VRZ血药浓度无关,可能与患者个体差异有关.
文献关键词:
环孢素A;伏立康唑;血药浓度;治疗药物监测;药物相互作用
作者姓名:
王亚妮;吴迪;饶志;李茂星;葸瑞;任俊
作者机构:
中国人民解放军联勤保障部队第940医院临床药学科, 甘肃 兰州 730050;陕西省宝鸡市中医医院临床药学室, 陕西 宝鸡 721000;宁夏医科大学药学院, 宁夏 银川750000;兰州大学第一医院药剂科, 甘肃 兰州 730050
引用格式:
[1]王亚妮;吴迪;饶志;李茂星;葸瑞;任俊-.异基因造血干细胞移植患者体内环孢素A和伏立康唑的相互作用)[J].药学实践与服务,2022(03):277-280
A类:
VRZ
B类:
异基因造血干细胞移植,环孢素,伏立康唑,Allo,HSCT,静脉滴注,CsA,药物相互作用,DDI,精准药物治疗,自身对照,对照研究,排除标准,LC,血药浓度,同一时间,Wilcoxon,符号秩,秩和检验,中位数,显著相关性,个体差异,治疗药物监测
AB值:
0.180478
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