典型文献
Metabolomic and elemental profiling of blood serum in bladder cancer
文献摘要：
Bladder cancer(BC)is one of the most frequently diagnosed types of urinary cancer.Despite advances in treatment methods,no specific biomarkers are currently in use.Targeted and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spec-trometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICP-OES).All results were subjected to multivariate statistical analysis.Four potential serum biomarkers of BC,namely,iso-butyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of 0.999.Two elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using LDI-MS.Five serum metab-olites were found to discriminate between tumor grades and nine metabolites between tumor stages.The results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC.
文献关键词：
中图分类号：
作者姓名：
Krzysztof Ossoliński;Tomasz Ruman;Valérie Copié;Brian P.Tripet;Leonardo B.Nogueira;Katiane O.P.C.Nogueira;Artur Ko?odziej;Aneta P?aza-Altamer;Anna Ossolińska;Tadeusz Ossoliński;Joanna Nizio?
作者机构：
Department of Urology,John Paul Ⅱ Hospital,36-100,Kolbuszowa,Poland;Rzeszów University of Technology,Faculty of Chemistry,35-959,Rzeszów,Poland;The Department of Chemistry and Biochemistry,Montana State University,Bozeman,MT,59717,USA;Department of Geology,Federal University of Ouro Preto,35400-000,Ouro Preto,Brazil;Department of Biological Sciences,Federal University of Ouro Preto,35400-000,Ouro Preto,Brazil;Doctoral School of Engineering and Technical Sciences at the Rzeszów University of Technology,35-959,Rzeszów,Poland
文献出处：
引用格式：
[1]Krzysztof Ossoliński;Tomasz Ruman;Valérie Copié;Brian P.Tripet;Leonardo B.Nogueira;Katiane O.P.C.Nogueira;Artur Ko?odziej;Aneta P?aza-Altamer;Anna Ossolińska;Tadeusz Ossoliński;Joanna Nizio?-.Metabolomic and elemental profiling of blood serum in bladder cancer)[J].药物分析学报（英文）,2022(06):889-900
A类：
pyroglutamate
B类：
Metabolomic,elemental,profiling,blood,serum,bladder,cancer,Bladder,BC,one,frequently,diagnosed,types,urinary,Despite,advances,treatment,methods,specific,biomarkers,currently,Targeted,untargeted,metabolites,elements,human,from,patients,same,number,normal,controls,NCs,external,validation,was,attempted,using,three,analytical,nuclear,magnetic,resonance,gold,silver,nanoparticle,laser,desorption,ionization,mass,LDI,inductively,coupled,plasma,optical,emission,spectrometry,ICP,OES,All,results,were,subjected,multivariate,statistical,analysis,Four,potential,namely,iso,butyrate,choline,acetate,quantified,proton,which,had,excellent,predictive,ability,judged,by,area,under,curve,value,Two,Li,also,found,distinguish,between,samples,data,set,Twenty,five,putatively,identified,compounds,mostly,related,glycans,lipids,differentiated,detected,Five,discriminate,tumor,grades,nine,stages,platforms,demonstrate,that,distinct,metal,have,used,noninvasive,detection,staging,grading
AB值：
0.618515
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
