典型文献
Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography
文献摘要：
In this research,a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine and ethylene dimethacrylate to mimick bio-membrane environment.Excellent physicochemical properties of this novel monolith that were achieved included column efficiency,stability,and permeability.Moreover,the biomimetic monolith showed outstanding separation capability for a series of intact proteins and small molecules.In particular,it exhibited good potential as an alternative to the commercial immobilized artificial membrane(IAM)column(IAM.PC.DD2)for studying drug-membrane interactions.This study not only enriched the types of IAM stationary phases,but also provided a simple model for the prediction of phosphatidylethanolamine related properties of drug candidates.
文献关键词：
中图分类号：
作者姓名：
Peijie Zhu;Weijia Chen;Qiqin Wang;Huihui Wu;Meng Ruan;Hongwu Wang;Zhengjin Jiang
作者机构：
School of Food&Pharmaceutical Engineering,Zhaoqing University,Zhaoqing,Guangdong,526061,China;Institute of Pharmaceutical Analysis,College of Pharmacy,Jinan University,Guangzhou,510632,China;School of Pharmaceutical Engineering,Guangdong Food and Drug Vocational College,Guangzhou,510632,China;Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New Drug Research,Jinan University,Guangzhou,510632,China
文献出处：
引用格式：
[1]Peijie Zhu;Weijia Chen;Qiqin Wang;Huihui Wu;Meng Ruan;Hongwu Wang;Zhengjin Jiang-.Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography)[J].药物分析学报（英文）,2022(02):332-338
A类：
Phosphatidylethanolamine,dodecanoyl,methacrylamidoundecanoyl,mimick,DD2
B类：
functionalized,biomimetic,monolith,immobilized,artificial,membrane,chromatography,In,this,research,new,phospholipid,was,fabricated,by,situ,polymerization,sn,glycero,phosphoethanolamine,ethylene,dimethacrylate,environment,Excellent,physicochemical,properties,novel,that,were,achieved,included,column,efficiency,stability,permeability,Moreover,showed,outstanding,separation,capability,series,intact,proteins,small,molecules,particular,exhibited,good,potential,alternative,commercial,IAM,studying,drug,interactions,This,not,only,enriched,types,stationary,phases,but,also,provided,simple,model,prediction,phosphatidylethanolamine,related,candidates
AB值：
0.626501
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