典型文献
Risk factors for Clostridioides difficile infection in children and adolescents with inflammatory bowel disease:a systematic review and meta-analysis
文献摘要：
Background Risk factors and consequences associated with Clostridioides difficile infection (CDI) in children and adoles-cents with inflammatory bowel disease (IBD) are still uncertain.We conduct a systematic review and meta-analysis to assess risk factors and outcomes associated with CDI in children and adolescents with IBD.Methods PubMed,EMBASE and Cochrane Library databases were searched from inception to 24th February,2021.Studies investigating risk factors,bowel surgery rate in pediatric IBD patients with and without CDI were included.Random-effects model was used for calculating summary estimates.Newcastle-Ottawa scale (NOS) was used for quality assessment.Results Fourteen studies,comprising 17,114 patients,were included.There was a significant association between 5-ami-nosalicylic acid (5-ASA) use and CDI[odds ratio (OR) =1.95,95％ confidence interval (CI) 1.26-3.03],with minimal heterogeneity (I2 =0.00％).Increased risk of active disease (OR =4.66,95％ CI 2.16-10.07) were associated with CDI in those studies performed in high quality score (NOS ＞ 6) and significantly higher CDI rates in studies conducted outside USA(OR =2.94,95％ CI 1.57-5.58).The bowel surgery rate in IBD with CDI was 3.8-57.1％,compared to that in IBD without CDI (0-21.3％).All studies were of moderate to high quality.Conclusions 5-ASA use and active disease might be risk factors associated with CDI in children and adolescents with IBD.Bowel surgery rates associated with CDI in IBD patients varied greatly.Large-scale clinical studies on CDI in children and adolescents with IBD are still needed to verify risk factors and outcomes.
文献关键词：
中图分类号：
作者姓名：
Sheng-Bo Fang;Yan-Qing Song;Chun-Yan Zhang;Li-Bo Wang
作者机构：
Department of Pharmacy,First Hospital of Jilin University,Changchun,China;Department of Pediatric Gastroenterology Unit,First Hospital of Jilin University,71 Xinmin Street,Changchun 130021,China
文献出处：
引用格式：
[1]Sheng-Bo Fang;Yan-Qing Song;Chun-Yan Zhang;Li-Bo Wang-.Risk factors for Clostridioides difficile infection in children and adolescents with inflammatory bowel disease:a systematic review and meta-analysis)[J].世界儿科杂志（英文版）,2022(01):27-36
A类：
ami,nosalicylic
B类：
Risk,factors,Clostridioides,difficile,infection,children,adolescents,inflammatory,bowel,disease,systematic,review,meta,analysis,Background,consequences,associated,CDI,IBD,still,uncertain,We,risk,outcomes,Methods,EMBASE,Cochrane,Library,databases,were,searched,from,inception,24th,February,Studies,investigating,surgery,pediatric,patients,without,included,Random,effects,model,was,used,calculating,summary,estimates,Newcastle,Ottawa,scale,NOS,quality,assessment,Results,Fourteen,studies,comprising,There,association,between,acid,ASA,odds,ratio,confidence,interval,minimal,heterogeneity,I2,Increased,active,those,performed,score,significantly,higher,rates,conducted,outside,USA,compared,that,All,moderate,Conclusions,might,Bowel,varied,greatly,Large,clinical,needed,verify
AB值：
0.439044
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