Objective: The effectiveness of adjuvant treatments for resected gallbladder carcinoma (GBC) has remained unclear due to lack of randomized controlled trials; thus, the aim of present study was to evaluate the role of adjuvant treatments, including chemoradiotherapy (CRT) and/or chemotherapy (CTx), in patients with resected GBC.Methods: A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional database. Of 733 patients, 372 (50.8％) did not receive adjuvant treatment, whereas 215 (29.3％) and 146 (19.9％) received adjuvant CTx and CRT, respectively. The locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS), and overall survival (OS) of the adjuvant treatment groups were compared according to tumor stage (stage Ⅱ vs. stage Ⅲ–IV). Results: In stage Ⅱ disease (n = 381), the 5-year LRFS, RFS, and OS were not significantly different among the no-adjuvant therapy, CTx, and CRT groups, and positive resection margin, presence of perineural invasion, and Nx classification were consistently associated with worse LRFS, RFS, and OS in the multivariate analysis (P < 0.05). For stage Ⅲ–IV (n = 352), the CRT group had significantly higher 5-year LRFS, RFS, and OS than the no-adjuvant therapy and CTx groups (67.8％, 45.2％, and 56.9％; 37.9％, 28.8％, and 35.4％; and 45.0％, 30.0％, and 45.7％, respectively) (P < 0.05). Conclusions: CRT has value as adjuvant treatment for resected GBC with stage Ⅲ–IV disease. Further study is needed for stage Ⅱ disease with high-risk features.

Sung Uk Lee;Jinsil Seong;Tae Hyun Kim;Jung Ho Im;Woo Chul Kim;Kyubo Kim;Hae Jin Park;Tae Gyu Kim;Youngkyong Kim;Bae Kwon Jeong;Jin Hee Kim;Byoung Hyuck Kim;Taek-Keun Nam

Center for Proton Therapy and Center for Liver and Pancreatobiliary Cancer,National Cancer Center,Goyang 10408,Korea;Department of Radiation Oncology,Yonsei Cancer Center,Yonsei University College of Medicine,Seoul 03722,Korea;Department of Radiation Oncology,CHA Bundang Medical Center,CHA University School of Medicine,Seongnam 13497,Korea;Department of Radiation Oncology,Inha University Hospital,Inha University School of Medicine,Incheon 22332,Korea;Department of Radiation Oncology,Ewha Womans University Mokdong Hospital,Ewha Womans University College of Medicine,Seoul 07985,Korea;Department of Radiation Oncology,Hanyang University Medical Center,Hanyang University College of Medicine,Seoul 04763,Korea;Department of Radiation Oncology,Samsung Changwon Hospital,Sungkyunkwan University School of Medicine,Changwon 51353,Korea;Department of Radiation Oncology,Kyung Hee University Hospital,Kyung Hee University College of Medicine,Seoul 02447,Korea;Department of Radiation Oncology,Gyeongsang National University Hospital,Gyeongsang National University College of Medicine,Jinju 52727,Korea;0Department of Radiation Oncology,Dongsan Medical Center,Keimyung University School of Medicine,Daegu 41931,Korea;1Department of Radiation Oncology,Seoul Metropolitan Government Seoul National University Boramae Medical Center,Seoul 07061,Korea;2Department of Radiation Oncology,Chonnam National University Hwasun Hospital,Chonnam National University College of Medicine,Hwasun 58128,Korea

癌症生物学与医学（英文版）

[1]Sung Uk Lee;Jinsil Seong;Tae Hyun Kim;Jung Ho Im;Woo Chul Kim;Kyubo Kim;Hae Jin Park;Tae Gyu Kim;Youngkyong Kim;Bae Kwon Jeong;Jin Hee Kim;Byoung Hyuck Kim;Taek-Keun Nam-.Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multi-institutional analysis (KROG 19-04))[J].癌症生物学与医学（英文版）,2022(06):931-944

KROG

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