典型文献
Highly Prevalent SARS-CoV-2 Antigenemia in COVID-19 Patients
文献摘要：
Background::Many issues, such as severity assessment and antibody responses, remain to be answered eagerly for evaluation and understanding of COVID-19. Immune lesion is one of key pathogenesis of the disease. It would be helpful to understand the disease if an investigation on antigenemia and association was conducted in the patients with SARS-CoV-2 infection.Methods::A total of 156 patients admitted to the First People’s Hospital of Hefei or Anhui Provincial Hospital on January to February 2020 were involved in this study. SARS-CoV-2 nucleocapsid (NP) antigen, specific IgM/IgG antibodies, and RNA were detected in sequential sera from three COVID-19 patients, and additional 153 COVID-19 patients by means of NP-antigen capture enzyme-linked immunosorbent assay, colloidal gold quick diagnosis, and real-time RT-PCR, respectively. The clinical types of COVID-19 patients were classified into asymptomatic, mild, moderate, severe, and critical, following on the Chinese guideline of COVID-19 diagnosis and treatment. The demographic and clinical data of patients were obtained for comparable analysis.Results::NP antigen was detected in 5 of 20 sequential sera collected from three COVID-19 patients with typically clinical symptoms, and 60.13% (92/153) expanded samples collected within 17 days after illness onset. No SARS-CoV-2 RNA segment was detected in these sera. The NP positive proportion reached a peak (84.85%, 28/33) on 6 to 8 days after illness onset. Both NP concentration and positive proportion were increased with the increase of clinical severity of COVID-19. Compared to NP negative patients, NP positive patients had older age [years, medians (interquartile ranges (IQR)), 49 (6)
vs. 31 (11)], lower positive proportion of NP specific IgM [27.17% (25/92)
vs. 59.02% (36/61)], and IgG [21.74% (20/92)
vs. 59.02% (36/61)] antibodies, and longer duration [days, medians (IQR), 24 (10)
vs. 21 (13)] from illness to recovery.
Conclusions::SARS-CoV-2 NP antigenemia occurred in COVID-19, and presented highly prevalent at early stage of the disease. The antigenemia was related to clinical severity of the disease, and may be responsible for the delay of detectable SARS-Cov-2 IgM.
文献关键词：
COVID-19;Antibody response;Antigenemia;Clinical severity;SARS-CoV-2
中图分类号：
作者姓名：
Zhang Wenyan;Liu Wei;Lin Jiawang;Jin Jing;Zhao Kefu;Zhu Liwei;Wang Xiuzhen;Wang Lijie;Tang Renshu;Zhu Yindi;Zhou Wei;You Enqing;Zhang Lei;Liu Xuxiang;Wu Jinju;Chen Lili;Wang Wenjing;Zhang Qiang;Gao Rongbao
作者机构：
Hefei Center for Disease Control and Prevention, Hefei, Anhui Province 230061, China;BIOHIT Healthcare (Hefei) Co., Hefei, Anhui Province 230000, China;The First People’s Hospital of Hefei, Hefei, Anhui Province 230091, China;Anhui Provincial Hospital, Hefei, Anhui Province 231501, China;State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China;NHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
文献出处：
引用格式：
[1]Zhang Wenyan;Liu Wei;Lin Jiawang;Jin Jing;Zhao Kefu;Zhu Liwei;Wang Xiuzhen;Wang Lijie;Tang Renshu;Zhu Yindi;Zhou Wei;You Enqing;Zhang Lei;Liu Xuxiang;Wu Jinju;Chen Lili;Wang Wenjing;Zhang Qiang;Gao Rongbao-.Highly Prevalent SARS-CoV-2 Antigenemia in COVID-19 Patients)[J].感染性疾病和免疫（英文）,2022(03):193-199
A类：
Prevalent,Antigenemia,antigenemia
B类：
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AB值：
0.5102
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