典型文献
Anatomical Evidence for the Neural Connection from the Emotional Brain to Autonomic Innervation in the Anterior Chamber Structures of the Eye
文献摘要：
Objective:Previous studies have shown that the autonomic nervous system(ANS),which can be affected by emotions,is important in the occurrence or progression of glaucoma.The autonomic innervation distributed in the anterior chamber(AC)structures might play an efferent role in the neural regulation of intraocular pressure(IOP).This study aimed to investigate the anatomic neural connection from the emotional brain to autonomic innervation in the AC.Methods:A retrograde trans-multisynaptic pseudorabies virus encoded with an enhanced green fluorescent protein(PRV531)and non-trans-synaptic tracer FAST Dil were injected into the right eye of mice,respectively.Fluorescent localization in the emotional brain and preganglionic nuclei was studied.Five and a half days after PRV531 injection into the right AC,fluorescent signals were observed in several emotional brain regions,including the amygdala,agranular insular cortex,lateral septal nuclei,periaqueductal gray,and hypothalamus.Autonomic preganglionic nuclei,including Edinger-Westphal nucleus,superior salivatory nucleus,and intermediolateral nucleus,were labeled using PRV531.Results:The sensory trigeminal nuclei were not labeled using PRV531.The fluorescence signals in the nuclei mentioned above showed bilateral distribution,primarily on the ipsilateral side.Seven days after injecting FAST Dil into the AC,we observed no FAST Dil-labeled neurons in the central nervous system.Conclusion:Our results indicate a neural connection from the emotional brain to autonomic innervation in the AC,which provides anatomical support for the emotional influence of IOP via the ANS.
文献关键词：
中图分类号：
作者姓名：
Lin MA;Fang YANG;Qing LIU;Xu-tao ZHU;Xin LIU;Sen JIN;Hua-dong WANG;Lei PEI;Fu-qiang XU;Hai-xia LIU
作者机构：
Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430033,China;Shenzhen Key Laboratory of Viral Vectors for Biomedicine,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences;Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China;State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Key Laboratory of Magnetic Resonance in Biological Systems,Wuhan Center for Magnetic Resonance,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan 430071,China;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Lin MA;Fang YANG;Qing LIU;Xu-tao ZHU;Xin LIU;Sen JIN;Hua-dong WANG;Lei PEI;Fu-qiang XU;Hai-xia LIU-.Anatomical Evidence for the Neural Connection from the Emotional Brain to Autonomic Innervation in the Anterior Chamber Structures of the Eye)[J].当代医学科学(英文),2022(02):417-425
A类：
Autonomic,Innervation,multisynaptic,PRV531,preganglionic,agranular,Edinger,Westphal,salivatory,intermediolateral
B类：
Anatomical,Evidence,Neural,Connection,from,Emotional,Brain,Anterior,Chamber,Structures,Eye,Objective,Previous,studies,have,shown,that,autonomic,nervous,system,ANS,which,can,affected,by,emotions,important,occurrence,progression,glaucoma,innervation,distributed,anterior,chamber,AC,structures,might,play,efferent,role,neural,regulation,intraocular,pressure,IOP,This,study,aimed,investigate,connection,emotional,brain,Methods,retrograde,trans,pseudorabies,virus,encoded,enhanced,green,fluorescent,protein,tracer,FAST,Dil,were,injected,into,right,eye,mice,respectively,Fluorescent,localization,nuclei,was,studied,Five,half,days,after,injection,signals,observed,several,regions,including,amygdala,insular,cortex,septal,periaqueductal,gray,hypothalamus,nucleus,superior,labeled,using,Results,sensory,trigeminal,not,fluorescence,mentioned,above,showed,bilateral,distribution,primarily,ipsilateral,side,Seven,injecting,neurons,central,Conclusion,Our,results,indicate,provides,anatomical,support,influence,via
AB值：
0.525438
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