典型文献
Oxidative Damage to BV2 Cells by Trichloroacetic Acid:Protective Role of Boron via the p53 Pathway
文献摘要：
This study aimed to investigate the neurotoxicity induced by trichloroacetic acid (TCA) and the possible protective mechanisms of boron (B). Mouse BV2 cells were treated with TCA (0, 0.39, 0.78, 1.56, 3.12, 6.25, or 12.5 mmol/L) and B (0, 7.8, 15.6, 31.25, 62.5, 125, 500, or 1,000 mmol/L) for 3 h and 24 h, respectively. Then, reactive oxygen species, and supernatant proinflammatory cytokine and protein levels were analyzed after 24 h of combined exposure. Beyond the dose-dependent decrease in the cellular viability, it clearly increased after B supplementation (P < 0.05). Moreover, B decreased oxidative damage, and significantly down-regulated IL-6 levels and up-regulated TNF-β production (P <0.05). B also decreased apoptosis via the p53 pathway. The present findings indicated that TCA may induce oxidative damage, whereas B mitigates these adverse effects by decreasing cell apoptosis.
文献关键词：
中图分类号：
作者姓名：
WANG Chong;HUANG Wei;LI Li;WANG Chao;SHI Ying;TANG Song;GU Wen;XU Yong Jun;ZHANG Li Xia;ZHANG Ming;DUAN Lian;ZHAO Kang Feng
作者机构：
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health,Chinese Center for Disease Control and Prevention, Beijing 100021, China;The Afffiliated Shunde Hospital of Guangzhou Medical University, Foshan 528315, Guangzhou, China
文献出处：
引用格式：
[1]WANG Chong;HUANG Wei;LI Li;WANG Chao;SHI Ying;TANG Song;GU Wen;XU Yong Jun;ZHANG Li Xia;ZHANG Ming;DUAN Lian;ZHAO Kang Feng-.Oxidative Damage to BV2 Cells by Trichloroacetic Acid:Protective Role of Boron via the p53 Pathway)[J].生物医学与环境科学（英文版）,2022(07):657-662,中插19
A类：
Trichloroacetic
B类：
Oxidative,Damage,BV2,Cells,by,Acid,Protective,Role,Boron,p53,Pathway,This,study,aimed,investigate,neurotoxicity,induced,trichloroacetic,acid,TCA,possible,protective,mechanisms,boron,Mouse,cells,were,treated,respectively,Then,reactive,oxygen,species,supernatant,proinflammatory,cytokine,protein,levels,analyzed,after,combined,exposure,Beyond,dose,dependent,cellular,viability,clearly,increased,supplementation,Moreover,decreased,oxidative,damage,significantly,down,regulated,production,also,apoptosis,pathway,present,findings,indicated,that,may,whereas,mitigates,these,adverse,effects,decreasing
AB值：
0.683704
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
