典型文献
Weather and Birth Weight: Different Roles of Maternal and Neonatal GPR61 Promoter Methylation
文献摘要：
Objectives It is unclear whether G protein-coupled receptor 61 (GPR61) affecting body weight, plays a role in the association between birth weight and weather. This study aimed to assess the effects of prenatal weather and GPR61 on birth weight. Methods A total of 567 mother-newborn pairs were recruited in Houzhai Center Hospital during 2011–2012. We detected the maternal and neonatal GPR61 promoter methylation levels, and obtained meteorological and air pollution data. Results A positive association was observed between maternal and neonatal GPR61 methylation levels, and both of them were affected by precipitation, relative humidity (RH) and daily temperature range (DTR). Birth weight was associated negatively with RH and positively with DTR (P < 0.05). A significant association was observed between birth weight and neonatal GPR61 methylation. We observed that maternal GPR61 methylation seemed to modify associations between weather and birth weight (Pinteraction < 0.10), while neonatal GPR61 methylation mediated the effects of RH and DTR on birth weight (P < 0.05). Conclusions Our findings revealed the significant associations among prenatal weather, GPR61 methylation and birth weight. Maternal GPR61 methylation may modify the susceptibility of birth weight to prenatal weather conditions, while neonatal GPR61 methylation may be a bridge of the effects of prenatal RH and DTR on birth weight.
文献关键词：
中图分类号：
作者姓名：
LI Zhi Yuan;GONG Yong Xiang;YANG Meng;CHAI Jian;SUN Ren Jie;LI Qin Yang;HE Ya Nan;HUANG Hui;ZHANG Ya Wei;BA Yue;ZHOU Guo Yu
作者机构：
Department of Environmental Health&Environment and Health Innovation Team,School of Public Health, Zhengzhou University,Zhengzhou 450001,Henan,China;National Health Commission Key Laboratory of Birth Defects Prevention,Henan Key Laboratory of Population Defects Prevention,Henan Institute of Reproduction Health Science and Technology,Zhengzhou 450002,Henan,China;Yellow River Institute for Ecological Protection&Regional Coordinated Development,Zhengzhou University,Zhengzhou 450001,Henan,China;Department of Environment Health Science,Yale University School of Public Health,New Haven,CT,USA
文献出处：
引用格式：
[1]LI Zhi Yuan;GONG Yong Xiang;YANG Meng;CHAI Jian;SUN Ren Jie;LI Qin Yang;HE Ya Nan;HUANG Hui;ZHANG Ya Wei;BA Yue;ZHOU Guo Yu-.Weather and Birth Weight: Different Roles of Maternal and Neonatal GPR61 Promoter Methylation)[J].生物医学与环境科学（英文版）,2022(03):181-193,前插1-前插4
A类：
GPR61,Houzhai
B类：
Weather,Birth,Weight,Different,Roles,Maternal,Neonatal,Promoter,Methylation,Objectives,It,unclear,whether,protein,coupled,receptor,affecting,body,weight,plays,role,between,birth,weather,This,study,aimed,assess,effects,prenatal,Methods,total,mother,newborn,pairs,were,recruited,Center,Hospital,during,detected,maternal,neonatal,promoter,methylation,levels,obtained,meteorological,pollution,data,Results,was,observed,both,them,affected,by,precipitation,relative,humidity,RH,daily,temperature,range,DTR,associated,negatively,positively,significant,that,seemed,modify,associations,Pinteraction,while,mediated,Conclusions,Our,findings,revealed,among,may,susceptibility,conditions,bridge
AB值：
0.433612
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
