典型文献
Inhibition of central axon regeneration:perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury
文献摘要：
Background:Failure of axon regeneration after spinal cord injury (SCI) underlies the paralysis that so profoundly affects patients' quality of life.Many factors are involved in the regeneration failure.Chondroitin sulfate proteoglycans (CSPGs),normal constituents of the perineuronal nets in central nervous system (CNS),are secreted at the injury site and initially were thought to act as a purely physical barrien In the past decade,the receptor-like protein tyrosine phosphatases,protein tyrosine phosphatase sigma (PTPσ),and leukocyte common antigen-related phosphatase (LAR),have been identified as transmembrane receptors for CSPGs.The two receptors for myelin-associated growth inhibitors,Nogo receptors 1 and 3 (NgR1 and NgR3) also have been found to bind with CSPGs (Sharma et al.,2012).These findings suggest that CSPGs inhibit regeneration by interacting with these receptors,initiating downstream inhibitory signaling (Figure 1).
文献关键词：
中图分类号：
作者姓名：
Jianli Hu;Li-Qing Jin;Michael E.Selzer
作者机构：
Shriners Hospitals Pediatric Research Center(Center for Neural Repair and Rehabilitation),Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA;Department of Neurology,Lewis Katz School of Medicine at Temple University,Philadelphia,PA,USA
文献出处：
引用格式：
[1]Jianli Hu;Li-Qing Jin;Michael E.Selzer-.Inhibition of central axon regeneration:perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury)[J].中国神经再生研究（英文版）,2022(09):1955-1956
A类：
lamprey,Chondroitin,CSPGs,perineuronal,barrien,NgR1,NgR3
B类：
Inhibition,central,axon,regeneration,perspective,from,chondroitin,sulfate,proteoglycans,spinal,cord,injury,Background,Failure,after,SCI,underlies,paralysis,that,profoundly,affects,patients,quality,life,Many,factors,are,involved,failure,normal,constituents,nets,nervous,system,CNS,secreted,site,initially,were,thought,purely,physical,past,decade,like,protein,tyrosine,phosphatases,sigma,PTP,leukocyte,common,antigen,related,LAR,have,been,identified,transmembrane,receptors,two,myelin,associated,growth,inhibitors,Nogo,also,bind,Sharma,These,findings,suggest,by,interacting,these,initiating,downstream,inhibitory,signaling,Figure
AB值：
0.574393
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
