典型文献
Long-term follow-up of haploidentical transplantation in relapsed/refractory severe aplastic anemia:a multicenter prospective study
文献摘要：
In recent decades,haploidentical stem cell transplantation(haplo-SCT)to treat severe aplastic anemia(SAA)has achieved remarkable progress.However,long-term results are still lacking.We conducted a multicenter prospective study involving SAA patients who underwent haplo-SCT as salvage therapy.Long-term outcomes were assessed,mainly focusing on survival and quality of life(QoL).Longitudinal QoL was prospectively evaluated during pretransplantation and at 3 and 5 years posttransplantation using the SF-36 scale in adults and the PedsQL 4.0 scale in children.A total of 287 SAA patients were enrolled,and the median follow-up was 4.56 years(range,3.01-9.05 years)among surviving patients.During the long-term follow-up,268 of 275 evaluable patients(97.5％)obtained sustained full donor chi-merism,and 93.4％had complete hematopoietic recovery.The estimated overall survival and failure-free survival for the whole cohort at 9 years were 85.4％±2.1％and 84.0％±2.2％,respectively.Age(≥18 years)and a poorer performance status(ECOG＞1)were identified as risk factors for survival outcomes.For QoL recovery after haplo-SCT,we found that QoL progressively improved from pretransplantation to the 3-year and 5-year time points with statistical significance.The occurrence of chronic graft versus host dis-ease was a risk factor predicting poorer QoL scores in both the child and adult cohorts.At the last follow-up,74.0％of children and 72.9％of adults returned to normal school or work.These inspiring long-term outcomes suggest that salvage transplantation with haploidentical donors can be routine practice for SAA patients without human leukocyte antigen(HLA)-matched donors.
文献关键词：
中图分类号：
作者姓名：
Lan-Ping Xu;Zheng-Li Xu;Shun-Qing Wang;De-Pei Wu;Su-Jun Gao;Jian-Min Yang;Ling-Hui Xia;Qi-Fa Liu;Ming Jiang;Hai Bai;Xi Zhang;Xin Wang;Xiao-Jun Huang
作者机构：
Peking University People's Hospital,Peking University Institute of Hematology,Beijing 100044,China;National Clinical Research Center for Hematologic Disease,Beijing 100044,China;Department of Hematology,Guangzhou First People's Hospital,Guangzhou 510180,China;Department of Hematology,The First Affiliated Hospital of Soochow University,Soochow 215004,China;Department of Hematology,The First Hospital of Jilin University,Changchun 130061,China;Department of Hematology,Changhai Hospital Affiliated to Second Military Medical University,Shanghai 200433,China;Department of Hematology,Xiehe Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430022,China;Department of Hematology,Nanfang Hospital Affiliated to Southern Medical University,Guangzhou 510515,China;Department of Hematology,The First Affiliated Hospital of Xinjiang Medical University,Urumchi 830054,China;Department of Hematology,General Hospital of Lanzhou Military Region of PLA,Lanzhou 730050,China;Medical Center of Hematology,The Second Affiliated Hospital of Army Medical University,Chongqing 400037,China;Department of Hematology,Shandong Provincial Hospital,Jinan 250021,China;Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China;Peking-Tsinghua Center for Life Sciences,Beijing 100044,China
文献出处：
引用格式：
[1]Lan-Ping Xu;Zheng-Li Xu;Shun-Qing Wang;De-Pei Wu;Su-Jun Gao;Jian-Min Yang;Ling-Hui Xia;Qi-Fa Liu;Ming Jiang;Hai Bai;Xi Zhang;Xin Wang;Xiao-Jun Huang-.Long-term follow-up of haploidentical transplantation in relapsed/refractory severe aplastic anemia:a multicenter prospective study)[J].科学通报（英文版）,2022(09):963-970
A类：
pretransplantation,evaluable,merism
B类：
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AB值：
0.519665
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