典型文献
Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection
文献摘要：
Studies have shown that myelin-associated glycoprotein(MAG)can inhibit axon regeneration after nerve injury.However,the effects of MAG on neuroma formation after peripheral nerve injury remain poorly understood.In this study,local injection of MAG combined with nerve cap made of chitin conduit was used to intervene with the formation of painful neuroma after sciatic nerve transfection in rats.After 8 weeks of combined treatment,the autotomy behaviors were reduced in rats subjected to sciatic nerve transfection,the mRNA expression of nerve growth factor,a pain marker,in the proximal nerve stump was decreased,the density of regenerated axons was decreased,the thickness of the myelin sheath was increased,and the ratio of unmyelinated to myelinated axons was reduced.Moereover,the percentage of collagen fiber area and the percentage of fibrosis marker alpha-smooth muscle actin positive staining area in the proximal nerve stump were decreased.The combined treatment exhibited superior effects in these measures to chitin conduit treatment alone.These findings suggest that MAG combined with chitin conduit synergistically inhibits the formation of painful neuroma after sciatic nerve transection and alleviates neuropathic pain.This study was approved by the Animal Ethics Committee of Peking University People's Hospital(approval No.2019PHE027)on December5,2019.
文献关键词：
中图分类号：
作者姓名：
Wei Pi;Ci Li;Meng Zhang;Wei Zhang;Pei-Xun Zhang
作者机构：
Department of Orthopedics and Trauma,Peking University People's Hospital,Peking University,Beijing,China;Key Laboratory of Trauma and Neural Regeneration,Peking University,Beijing,China;National Center for Trauma Medicine,Beijing,China
文献出处：
引用格式：
[1]Wei Pi;Ci Li;Meng Zhang;Wei Zhang;Pei-Xun Zhang-.Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection)[J].中国神经再生研究（英文版）,2022(06):1343-1347
A类：
neuroma,autotomy,unmyelinated,myelinated,Moereover,2019PHE027,December5
B类：
Myelin,associated,glycoprotein,combined,chitin,conduit,inhibits,painful,formation,after,sciatic,nerve,transection,Studies,have,shown,that,MAG,can,regeneration,injury,However,effects,peripheral,remain,poorly,understood,In,this,study,local,injection,cap,made,was,used,intervene,transfection,rats,After,weeks,treatment,behaviors,were,reduced,subjected,expression,growth,marker,proximal,stump,decreased,density,regenerated,axons,thickness,sheath,increased,percentage,collagen,fiber,area,fibrosis,alpha,smooth,muscle,actin,positive,staining,exhibited,superior,these,measures,alone,These,findings,suggest,synergistically,alleviates,neuropathic,This,approved,by,Animal,Ethics,Committee,Peking,University,People,Hospital,approval,No
AB值：
0.45453
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