典型文献
The role of miRNA in retinal ganglion cell health and disease
文献摘要：
miRNA are short non-coding RNA responsible for the knockdown of proteins through their targeting and silencing of complimentary mRNA sequences. The miRNA landscape of a cell thus affects the levels of its proteins and has significant consequences to its health. Deviations in this miRNA landscape have been implicated in a variety of neurodegenerative diseases and have also garnered interest as targets for treatment. Retinal ganglion cells are the sole projection neuron of the retina with their axons making up the optic nerve. They are a focus of study not only for their importance in vision and the myriad of blinding diseases characterized by their dysfunction and loss, but also as a model of other central nervous system diseases such as spinal cord injury and traumatic brain injury. This review summarizes current knowledge on the role of miRNA in retinal ganglion cell function, highlighting how perturbations can result in disease, and how modulating their abundance may provide a novel avenue of therapeutic research.
文献关键词：
中图分类号：
作者姓名：
Ben Mead
作者机构：
School of Optometry and Vision Sciences,Cardiff University,Cardiff,UK;Section of Retinal Ganglion Cell Biology,Laboratory of Retinal Cell and Molecular Biology,National Eye Institute,National Institutes of Health,Bethesda,MD,USA
文献出处：
引用格式：
[1]Ben Mead-.The role of miRNA in retinal ganglion cell health and disease)[J].中国神经再生研究（英文版）,2022(03):516-522
A类：
Deviations
B类：
role,miRNA,retinal,ganglion,health,are,short,coding,responsible,knockdown,proteins,through,their,targeting,silencing,complimentary,landscape,thus,affects,levels,its,has,significant,consequences,this,have,been,implicated,variety,neurodegenerative,diseases,also,garnered,interest,targets,treatment,Retinal,cells,sole,projection,neuron,axons,making,up,optic,nerve,They,focus,study,not,only,importance,vision,myriad,blinding,characterized,by,dysfunction,loss,but,model,other,central,nervous,system,such,spinal,cord,injury,traumatic,brain,This,review,summarizes,current,knowledge,highlighting,how,perturbations,result,modulating,abundance,may,provide,novel,avenue,therapeutic,research
AB值：
0.634114
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
