Susan R.Goulding-Department of Anatomy and Neuroscience,and Cork Neuroscience Centre,University College Cork,Cork,Ireland;Department of Physiology,University College Cork,Cork,Ireland

Alisa A.Shaimardanova-Institute of Fundamental Medicine and Biology,Kazan Federal University,Kazan,Russia

Alberto F.Cintrón-Colón-Biological Sciences Department,Western Michigan University,Kalamazoo,MI,USA

Sanaz Behtaj;James A.St John;Jenny A.K.Ekberg;Maksym Rybachuk-Clem Jones Centre for Neurobiology and Stem Cell Research,Griffith University,Queensland,Australia;Menzies Health Institute Queensland,Griffith University,Southport,Australia;Griffith Institute for Drug Discovery,Nathan,Australia;School of Engineering and Built Environment,Griffith University,Nathan,Australia;Centre for Quantum Dynamics and Australian Attosecond Science Facility,Griffith University,Nathan,Australia

Diego García-Ayuso;Johnny Di Pierdomenico;David García-Bernal;Manuel Vidal-Sanz;María P.Villegas-Pérez-Departamento de Oftalmología,Facultad de Medicina,Universidad de Murcia,Campus de Ciencias de la salud,Murcia,Spain;Instituto Murciano de Investigación Biosanitaria Hospital Virgen de la Arrixaca (IMIB-Virgen de la Arrixaca),Murcia,Spain;Servicio de Hematología,Hospital Clínico Universitario Virgen de la Arrixaca,Murcia,Spain

Meng Zhang;Ci Li;Song-Yang Liu;Feng-Shi Zhang;Pei-Xun Zhang-Department of Orthopedics and Trauma,Peking University People's Hospital,Beijing,China;Key Laboratory of Trauma and Neural Regeneration,Peking University,Beijing,China;National Center for Trauma Medicine,Beijing,China

Hongpu Wei;Jinjie Cui;Kaili Lin;Jing Xie;Xudong Wang-Department of Oral&Cranio-Maxillofacial Surgery,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China;State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

Kai Dai;Shunshu Deng;Yuanman Yu;Fuwei Zhu;Jing Wang;Changsheng Liu-State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,P.R.China;Engineering Research Center for Biomedical Materials of Ministry of Education,East China University of Science and Technology,Shanghai,P.R.China;Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai,P.R.China;Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai,P.R.China

Sipin Zhu;Min Chen;Yibo Ying;Qiuji Wu;Zhiyang Huang;Wenfei Ni;Xiangyang Wang;Huazi Xu;Samuel Bennett;Jian Xiao;Jiake Xu-Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Molecular Pharmacology Research Centre,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,Zhejiang 325035,China;Molecular Laboratory,School of Biomedical Sciences,The University of Western Australia,Perth,WA 6009,Australia

Caizhi Liu;Xingcheng Gao;Yuheng Li;Weijia Sun;Youjia Xu;Yingjun Tan;Ruikai Du;Guohui Zhong;Dingsheng Zhao;Zizhong Liu;Xiaoyan Jin;Yinlong Zhao;Yinbo Wang;Xinxin Yuan;Junjie Pan;Guodong Yuan;Youyou Li;Wenjuan Xing;Guanghan Kan;Yanqing Wang;Qi Li;Xuan Han;Jianwei Li;Shukuan Ling;Yingxian Li-State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center,Beijing,China;The Key Laboratory of Aerospace Medicine,Ministry of Education,The Fourth Military Medical University,Xi'an,Shaanxi,China;The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu,China;College of Life Sciences,Hebei Normal University,Shijiazhuang,Hebei,China;Medical College of Soochow University,Suzhou,Jiangsu,China;Medical School of Southeast University,Nanjing,Jiangsu,China

Gaoyang Chen;Canling Long;Shang Wang;Zhenmin Wang;Xin Chen;Wanze Tang;Xiaoqin He;Zhiteng Bao;Baoyu Tan;Jin Zhao;Yongheng Xie;Zhizhong Li;Dazhi Yang;Guozhi Xiao;Songlin Peng-Department of Spine Surgery and Institute for Orthopaedic Research,the Second Clinical Medical College of Jinan University(Shenzhen People's Hospital),Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration,Shenzhen 518020,China;The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen 518055,China;The First Affiliated Hospital,Jinan University,Guangzhou 510630,China;School of Medicine,Southern University of Science and Technology,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Shenzhen 518055,China

Qianju Wu;Longwei Hu;Ran Yan;Junfeng Shi;Hao Gu;Yuwei Deng;Ruixue Jiang;Jin Wen;Xinquan Jiang-Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University,National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, China;Stomatological Hospital of Xiamen Medical College, Xiamen, Fujian 361008, China;Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, China

Xin Sun;Xin Zhang;Xin Jiao;Jie Ma;Xingzhen Liu;Han Yang;Kangping Shen;Yaokai Gan;Jinwu Wang;Haiyan Li;Wenjie Jin-Shanghai Key Laboratory of Orthopaedic Implants,Department of Orthopaedic Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200001,China;School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China;Chemical and Environmental Engineering,School of Engineering,RMIT University,124 La Trobe St.,Melbourne,VIC 3000,Australia

Maryam Tamaddon;Gordon Blunn;Rongwei Tan;Pan Yang;Xiaodan Sun;Shen-Mao Chen;Jiajun Luo;Ziyu Liu;Ling Wang;Dichen Li;Ricardo Donate;Mario Monzón;Chaozong Liu-Institute of Orthopaedic and Musculoskeletal Science,Royal National Orthopaedic Hospital,University College London,Stanmore HA7 4LP,UK;School of Pharmacy and Biomedical Sciences,University of Portsmouth,Portsmouth PO1 2DT,UK;Guangdong Engineering Research Center of Implantable Medical Polymer,Shenzhen Lando Biomaterials Co.,Ltd.,Shenzhen 518107,China;School of Materials Science and Engineering,Tsinghua University,Beijing 100084,China;State Key Laboratory for Manufacturing System Engineering,School of Mechanical Engineering,Xi'an Jiaotong University,Xi'an 710054,China;Departamento de Ingeniería Mecánica,Grupo de Investigación en Fabricación Integrada y Avanzada,Universidad de Las Palmas de Gran Canaria,Campus Universitario de Tafira s/n,35017 Las Palmas,Spain

Yage Sun;Ziwei Gao;Xiaoping Zhang;Ziyang Xu;Yahan Zhang;Binbin He;Rong Yang;Qian Zhang;Qiang Yang;Wenguang Liu-School of Material Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300350,China;Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin 300211,China

Rong Li;Songzuo Yu;Xiao Liang;Yu Li;Keng Po Lai-Laboratory of Environmental Pollution and Integrative Omics,Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guilin 541004,China;Department of Neurosurgery,Guigang City People's Hospital,The Eighth Affiliated Hospital of Guangxi Medical University,Guigang 537100,China

Fangying Zhao;Yafang Lu;Zhifan Li;Jiangyong He;Nianfei Cui;Lingfei Luo;Li Li-Institute of Developmental Biology and Regenerative Medicine,Key Laboratory of Freshwater Fish Reproduction and Development,Ministry of Education,Southwest University,Chongqing 400715,China;Research Center of Stem Cells and Ageing,Chongqing Institute of Green and Intelligent Technology,Chinese Academy of Sciences,Chongqing 400714,China

Kaspiris Angelos;Chronopoulos Efstathios;Vasiliadis Elias;Khaldi Lubna;Melissaridou Dimitra;Iliopoulos Ilias D.;Savvidou Olga D.-Laboratory of Molecular Pharmacology, Division for Orthopaedic Research, School of Health Sciences, University of Patras, Patras, Greece;Second Department of Orthopaedic Surgery, School of Medicine, National and Kapodistrian University of Athens, "Konstantopoulio" General Hospital, Athens, Greece;Third Department of Orthopaedic Surgery, "KAT" General Hospital and Medical School, University of Athens, Athens, Greece;Department of Pathology, "Agios Savvas" Athens Cancer Hospital-NHS, Athens, Greece;First Department of Orthopaedic Surgery, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University General Hospital, Athens, Greece;Department of Orthopaedic Surgery, "Rion" University Hospital and Medical School, School of Health Sciences, University of Patras, Patras, Greece

Yuteng Weng;Haicheng Wang;Di Wu;Shuyu Xu;Xiaofan Chen;Jie Huang;Yanhuizhi Feng;Lin Li;Zuolin Wang-Department of Oral Implantology & Department of Oral and Maxillofacial Surgery,Stomatological Hospital and Dental School of Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai,China

Liu-shan Chen;Meng Zhang;Peng Chen;Xiao-feng Xiong;Pei-qing Liu;Hai-bin Wang;Jun-jian Wang;Juan Shen-Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances,Guangdong Pharmaceutical University,Guangzhou 510006,China;Department of Orthopedics,Henan Provincial People's Hospital,People's Hospital of Zhengzhou University,People's Hospital of Henan University,Zhengzhou 450003,China;The First Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China