Bing Wang;Huizeng Sun;Diming Wang;Hongyun Liu;Jianxin Liu-Institute of Dairy Science,MoE Key Laboratory of Molecular Animal Nutrition,College of Animal Sciences,Zhejiang University,Hangzhou,China;State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,Beijing,China

Priscila Chiavellini-Biochemistry Research Institute of La Plata(INIBIOLP)-Histology and Embryology B,School of Medical Sciences,National University of La Plata(UNLP),La Plata,Buenos Aires,Argentina

Philippe Pihán;Mateus Milani;Claudio Hetz-Biomedical Neuroscience Institute,Faculty of Medicine,University of Chile,Santiago,Chile;Center for Geroscience,Brain Health and Metabolism(GERO),Santiago,Chile;Program of Cellular and Molecular Biology,Institute of Biomedical Sciences,University of Chile,Santiago,Chile;Buck Institute for Research on Aging,Novato,CA,USA

Yanshen Nie;Li Yu;Lianlian Mao;Wenxuan Zou;Xiufeng Zhang;Jie Zhao-State Key Laboratory of Hybrid Rice,College of Life Sciences,Wuhan University,Wuhan 430072,China

Steve Stegen;Shauni Loopmans;Ingrid Stockmans;Karen Moermans;Peter Carmeliet;Geert Carmeliet-Laboratory of Clinical and Experimental Endocrinology,Department of Chronic Diseases and Metabolism,KU Leuven,3000 Leuven,Belgium;Laboratory of Angiogenesis and Vascular Metabolism,VIB Center for Cancer Biology,3000 Leuven,Belgium;Laboratory of Angiogenesis and Vascular Metabolism,Department of Oncology and Leuven Cancer Institute,KU Leuven,3000 Leuven,Belgium;State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou 510080,China

Mingxiang Cai;Baichuan Xiao;Fujun Jin;Xiaopeng Xu;Yuwei Hua;Junhui Li;Pingping Niu;Meijing Liu;Jiaqi Wu;Rui Yue;Yong Zhang;Zuolin Wang;Yongbiao Zhang;Xiaogang Wang;Yao Sun-Department of Oral Implantology,School of Stomatology,Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China;The First Affiliated Hospital of Jinan University,School of Stomatology,Clinical Research Platform for Interdiscipline of Stomatology,Jinan University,Guangzhou 510630,China;Key Laboratory of Big Data-Based Precision Medicine,School of Engineering Medicine,Beihang University,Beijing 100191,China;Guangzhou Laboratory,Bioland Laboratory,Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou 510320,China;Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China

Zheng Li;Fang Yao;Peng Yu;Dandan Li;Mingzhi Zhang;Lin Mao;Xiaomeng Shen;Zongna Ren;Li Wang;Bingying Zhou-Shenzhen Key Laboratory of Cardiovascular Disease,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen 518057,China;State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Key Laboratory of Pluripotent Stem Cells in Cardiac Repair and Regeneration,Chinese Academy of Medical Sciences,Beijing 100037,China;State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,People's Republic of China

Hanwen Li;Jinqiang Nian;Shuang Fang;Meng Guo;Xiahe Huang;Fengxia Zhang;Qing Wang;Jian Zhang;Jiaoteng Bai;Guojun Dong;Peiyong Xin;Xianzhi Xie;Fan Chen;Guodong Wang;Yingchun Wang;Qian Qian;Jianru Zuo;Jinfang Chu;Xiaohui Ma-State Key Laboratory of Plant Genomics,National Center for Plant Gene Research(Beijing),Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;College of Advanced Agricultural Sciences,University of Chinese Academy of Sciences,Beijing 100049,China;State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;Innovation Academy for Seed Design,Chinese Academy of Sciences,Beijing 100101,China;State Key Laboratory of Rice Biology,China National Rice Research Institute,Chinese Academy of Agricultural Sciences,Hangzhou,Zhejiang 310006,China;Institute of Wetland Agriculture and Ecology,Shandong Academy of Agricultural Sciences,Jinan,Shandong 250100,China;Hainan Yazhou Bay Laboratory,Sanya,Hainan 572025,China;CAS Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences,Beijing 100101,China

Xuerui Lu;Shixi Shi;Chong Wu;Xueao Zheng;Chenkun Yang;Jie Luo;Shunping Yan-Hubei Hongshan Laboratory,Wuhan,Hubei 430070,China;College of Life Science and Technology,Huazhong Agricultural University,Wuhan,Hubei 430070,China;National Key Laboratory of Crop Genetic Improvement,Huazhong Agricultural University,Wuhan,Hubei 430070,China

Zu-Wen Zhou;Zhi-Guang Yu;Xiao-Ming Huang;Jin-Shen Liu;Yi-Xiong Guo;Ling-Ling Chen;Jia-Ming Song-State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources,College of Life Science and Technology,Guangxi University,Nanning,Guangxi 530004,China;College of Stomatology,Guangxi Medical University,Nanning,Guangxi 530021,China;National Key Laboratory of Crop Genetic Improvement,Huazhong Agricultural University,Wuhan,Hubei 430070,China

Zhou Li;Luo Hong;Lee Jae Woo-Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China;Department of Anesthesiology, University of California, San Francisco, San Francisco, California 94143, USA

Wang Ying;Wang Dan;Yang Li;Zhang Yi-Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China;School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China;Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan 450052, China;State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan 450052, China

Zhao Simin;Zheng Baisong;Wang Liuli;Cui Wenzhe;Jiang Chunlai;Li Zhuo;Gao Wenying;Zhang Wenyan-Center for Pathogen Biology and Infectious Diseases, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin 130021, China;College of Life Science of Jilin University, Changchun, Jilin 130012, China;Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130012, China;Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China;Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin 130021, China

Qudsia Tabassam;Tahir Mehmood;Sibtain Ahmed;Farooq Anwar;Abdul Rauf Raza-Institute of Chemistry,University of Sargodha,Sargodha-40100-,Pakistan;Institute of Chemistry,University of Sargodha,Sargodha-40100,Pakistan;Institute of Biochemistry and Biotechnology,University of Veterinary and Animal Sciences-UVAS,54000-Lahore.Pakistan;University of California San Diego,9500 Gilman Drive La Jolla,CA 92093,USA

Fengwei Li;Chun Song;Youming Zhang;Dalei Wu-Helmholtz International Lab,State Key Laboratory of Microbial Technology,Shandong University,Qingdao 266237,China

Wu Liu;Yunfeng Long;Yongfen Bao;Yang Li;Mengxue Deng;Xiuyi Yang;He Zhu;Yanting Su-Hubei Key Laboratory of Diabetes and Angiopathy,Xianning Medical Colloge,Hubei University of Science and Technology,Xianning 437100,China;School of Pharmacy,Xianning Medical Colloge,Hubei University of Science and Technology,Xianning 437100,China;School of Basic Medical Sciences,Xianning Medical Colloge,Hubei University of Science and Technology,Xianning 437100,China;Colllege of Life Sciences,Wuhan University,Wuhan 430072,China;Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Wuhan 430030,China

Xi Gu;Xinde Hu;Daqi Wang;Zhijiao Xu;Fang Wang;Di Li;Geng-lin Li;Hui Yang;Huawei Li;Erwei Zuo;Yilai Shu-ENT institute and Department of Otorhinolaryngology,Eye & ENT Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai,China;Institutes of Biomedical Sciences,Fudan University,Shanghai,China;Department of Otolaryngology,the First Affiliated Hospital of Fujian Medical University,Fuzhou,China;NHC Key Laboratory of Hearing Medicine(Fudan University),Shanghai,China;Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China;State Key Lab for Conservation and Utilization of Subtropical Agric-Biological Resources,Guangxi University,Nanning,China;Shenzhen Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Genome Analysis Laboratory of the Ministry of Agriculture,Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,Shenzhen,China;The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science,Fudan University,Shanghai,China

Mao-Zhou Zhao;Di-Hang Lin;Heng Zuo;Huan Wei;Xin Wang;Lan-Tao Gou;Mo-Fang Liu-State Key Laboratory of Molecular Biology,State Key Laboratory of Cell Biology,Shanghai Key Laboratory of Molecular Andrology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences;School of Life Science and Technology,Shanghai Tech University,Shanghai,China;University of Chinese Academy of Sciences,Shanghai,China;School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang,China

Liang Chen;Jie Zhang;Zhun Lin;Ziyan Zhang;Miao Mao;Jiacheng Wu;Qian Li;Yuanqing Zhang;Chunhai Fan-School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China;School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China;Institute of Molecular Medicine,Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China

Shilin Chen;Zheng Li;Sanyin Zhang;Yuxin Zhou;Xiaohe Xiao;Pengdi Cui;Binjie Xu;Qinghe Zhao;Shasha Kong;Yuntao Dai-Institute of Herbgenomics,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;State Key Laboratory of Component Traditional Chinese Medicine,College of Pharmaceutical Engineering of Traditional Chinese Medicine,Haihe Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;China Military Institute of Chinese Medicine,Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China