典型文献
Generation of sulfonylureas under photoredox catalysis and their biological evaluations
文献摘要：
Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to pre-synthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate scope.With the insertion of commercialized chlorosulfonyl isocyanate under photoredox catal-ysis,alkylsulfonylureas are synthesized in one-pot from the corresponding anilines and silyl enolates.A reaction mechanism is proposed showing the transformation undergoes a radical process,and the practi-cality of this methodology is proven via application to bioactive molecules.Additionally,the anti-cancer and anti-virus screening of these compounds is evaluated.
文献关键词：
中图分类号：
作者姓名：
Xuefeng Wang;Jun Zhang;Qi Chen;Wei Zhou;Jie Wu
作者机构：
Taizhou Central Hospital(Taizhou University Hospital)&School of Pharmaceutical and Materials Engineering,Taizhou University,Taizhou 318000,China;Department of Chemistry,Fudan University,Shanghai 200438,China;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China
文献出处：
引用格式：
[1]Xuefeng Wang;Jun Zhang;Qi Chen;Wei Zhou;Jie Wu-.Generation of sulfonylureas under photoredox catalysis and their biological evaluations)[J].中国化学快报（英文版）,2022(11):4860-4864
A类：
arylsulfonamides,isocyanates,alkylsulfonylureas,chlorosulfonyl,silyl,enolates,cality
B类：
Generation,photoredox,catalysis,their,biological,evaluations,Traditional,synthesis,largely,depends,nucleophilic,addition,pre,synthesized,Now,we,report,new,access,good,yields,broad,substrate,scope,With,insertion,commercialized,are,one,pot,from,corresponding,anilines,reaction,mechanism,proposed,showing,transformation,undergoes,radical,process,practi,this,methodology,proven,via,application,bioactive,molecules,Additionally,anti,cancer,virus,screening,these,compounds,evaluated
AB值：
0.582651
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