典型文献
Integration of enzyme immobilization and biomimetic catalysis in hierarchically porous metal-organic frameworks for multi-enzymatic cascade reactions
文献摘要：
Multiple enzymes-induced biological cascade catalysis is indispensable in biotechnology and industrial processes.Nevertheless,the drawbacks of most natural enzymes,including poor stability and recyclability and sensitivity to the environment,have hindered their broader application.Here,we report a facile strategy to prepare a biomimetic cascade reaction system by combining the advantages of enzyme immobilization and biomimetic catalysis in a one-pot reaction system based on the hierarchically porous metal-organic frameworks(HP-MOFs).The hierarchically porous zirconium-porphyrin-based MOF(HP-PCN-222(Fe))synthesized by modulator-induced strategy possessed tunable hierarchical porous and peroxidase-like activity,permitting them to act as not only an efficient immobilization matrix for glucose oxidase(GOx)but also peroxidase mimics to catalyze the cascade for glucose detection.A stable,anti-interference and reusable colorimetric biosensor for glucose detection was successfully established through GOx@HP-PCN-222(Fe)on the basis of the artificial tandem catalysis.Moreover,the GOx@HP-PCN-222(Fe)-fabricated electrode was available for glucose detection by electrochemical method.This work pro-vides a potentially universal method to design functional multi-enzymatic cascade reaction systems by integrating the merits of enzyme encapsulation and biomimetic catalysis in HP-MOFs.
文献关键词：
中图分类号：
作者姓名：
Shu-Fan Li;Yan Chen;Yi-Shu Wang;Hui-Lin Mo;Shuang-Quan Zang
作者机构：
Henan Key Laboratory of Crystalline Molecular Functional Materials,Henan International Joint Laboratory of Tumor Theranostical Cluster Materials,Green Catalysis Center College of Chemistry,Zhengzhou University,Zhengzhou 450001,China;School of Chemistry and Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China
文献出处：
引用格式：
[1]Shu-Fan Li;Yan Chen;Yi-Shu Wang;Hui-Lin Mo;Shuang-Quan Zang-.Integration of enzyme immobilization and biomimetic catalysis in hierarchically porous metal-organic frameworks for multi-enzymatic cascade reactions)[J].中国科学:化学（英文版）,2022(06):1122-1128
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B类：
Integration,immobilization,biomimetic,catalysis,hierarchically,porous,metal,organic,frameworks,multi,enzymatic,cascade,reactions,Multiple,enzymes,induced,biological,indispensable,biotechnology,industrial,processes,Nevertheless,drawbacks,most,natural,including,poor,stability,recyclability,sensitivity,environment,have,hindered,their,broader,application,Here,we,report,facile,strategy,prepare,by,combining,advantages,one,HP,MOFs,zirconium,porphyrin,PCN,synthesized,modulator,possessed,tunable,peroxidase,like,activity,permitting,them,not,only,efficient,matrix,glucose,GOx,but,also,mimics,catalyze,detection,stable,anti,interference,reusable,colorimetric,biosensor,was,successfully,established,through,basis,artificial,tandem,Moreover,fabricated,electrode,available,electrochemical,method,This,vides,potentially,universal,design,functional,systems,integrating,merits,encapsulation
AB值：
0.550399
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