Neuromuscular blocking agents(NMBAs)are extensively used during anesthesia to improve surgical con-ditions by relaxing skeletal muscle movements.Rapid neuromuscular recovery after surgery is desirable to facilitate the recovery of muscle function and prevent residual blockade.Decamethonium(C10)is a classic NMBA,which has been restricted over the past decades ascribed to lack of a suitable antidote in clinic.Herein we used carboxylatopillar[6]arene(CP6A)to reverse neuromuscular blocker effect of C10 through direct host-guest encapsulation.NMR and isothermal titration calorimetry served to confirm the complexation between CP6A and C10 with robust affinity[(1.07±0.14)×107 L/mol].The CP6A was fur-ther used as a reversal agent of C10,which facilitated to decrease C10 concentration in mice blood and excrete via urinary clearance,resulting in rapid recovery from muscle relaxation.These favorable out-comes might lead us to suggest that this supramolecular strategy could allow patients to regain lucidity much faster than spontaneous recovery from anesthesia.

Yao Chai;Longming Chen;Yahan Zhang;Liang Zhao;Zhao Meng;Junyi Chen;Chunju Li;Qingbin Meng

State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China;Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry,Ministry of Education,Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China;Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain,Affiliated Ministry of Education,College of Pharmacy,Yanbian University,Yanji 133002,China

中国化学快报（英文版）

[1]Yao Chai;Longming Chen;Yahan Zhang;Liang Zhao;Zhao Meng;Junyi Chen;Chunju Li;Qingbin Meng-.Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation)[J].中国化学快报（英文版）,2022(06):3003-3006

decamethonium,carboxylatopillar,NMBAs,Decamethonium,antidote,CP6A,lucidity

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