典型文献
Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters:Chiral spiro-fused bisoxazoline ligands with 1,1'-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction
文献摘要：
A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared.The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction,affording the products bearing a trifluoromethylated all-carbon quaternary stere-ocenter with moderate to excellent yields(up to 99％)and good to excellent enantioselectivies(up to＞99.9％ee).Moreover,a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.
文献关键词：
中图分类号：
作者姓名：
Robert Li-Yuan Bao;Lei Shi;Kang Fu
作者机构：
School of Science,Harbin Institute of Technology,Shenzhen 518055,China;State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China;Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen 518055,China;School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China
文献出处：
引用格式：
[1]Robert Li-Yuan Bao;Lei Shi;Kang Fu-.Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters:Chiral spiro-fused bisoxazoline ligands with 1,1'-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction)[J].中国化学快报（英文版）,2022(05):2415-2419
A类：
stereocenters,bisoxazoline,sidearm,trifluoromethylated,stere,ocenter,enantioselectivies,nitroalkene
B类：
Highly,enantioselective,construction,CF3,bearing,all,carbon,quaternary,Chiral,spiro,fused,ligands,binaphthyl,asymmetric,Michael,type,Friedel,Crafts,reaction,novel,class,chiral,possessing,deep,pocket,was,prepared,developed,have,been,employed,nickel,catalyzed,highly,affording,products,moderate,excellent,yields,up,good,Moreover,proposed,model,revealed,that,attack,indole,from,Re,face,disubstituted,favorable
AB值：
0.518668
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
