典型文献
Super-resolution imaging reveals the subcellular distribution of dextran at the nanoscale in living cells
文献摘要：
Theranostic visualization of dextran at the nanoscale is beneficial for understanding the bioregulatory mechanisms of this molecule.In this study,we applied structured illumination microscopy(SIM)to cap-ture the distribution of Cy5-Dextran at different incubation periods in living cells.The results showed that Cy5-Dextran could be absorbed by HeLa cells.In addition,we clarified that Cy5-Dextran exhibited differential organelle distribution(lysosomal or mitochondrial)in a time-dependent manner.Moreover,lysosomal Cy5-Dextran localization was found to be independent of the autophagy process,while Cy5-Dextran localized to the mitochondria triggered a pro-apoptotic event,upregulating the levels of reactive oxygen species(ROS)to accelerate mitochondrial fragmentation.This work uses a visualized strategy to reveal the anti-tumor bioactivity of dextran,which was achieved by regulating apoptosis and autophagy.
文献关键词：
中图分类号：
作者姓名：
Huimin Chen;Han Wang;Yongchun Wei;Maomao Hu;Bo Dong;Hongbao Fang;Qixin Chen
作者机构：
Institute of Materia Medica,Shandong First Medical University&Shandong Academy of Medical Sciences,Ji'nan 250062,China;Department of Cardiology,Shandong Provincial Hospital Affiliated to Shandong University,Ji'nan 250012,China;State Key Laboratory of Coordination Chemistry,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China
文献出处：
引用格式：
[1]Huimin Chen;Han Wang;Yongchun Wei;Maomao Hu;Bo Dong;Hongbao Fang;Qixin Chen-.Super-resolution imaging reveals the subcellular distribution of dextran at the nanoscale in living cells)[J].中国化学快报（英文版）,2022(04):1865-1869
A类：
bioregulatory
B类：
Super,resolution,imaging,reveals,subcellular,distribution,dextran,nanoscale,living,cells,Theranostic,visualization,beneficial,understanding,mechanisms,this,molecule,In,study,applied,structured,illumination,microscopy,SIM,cap,Cy5,Dextran,incubation,periods,results,showed,that,could,absorbed,by,HeLa,addition,clarified,exhibited,differential,organelle,lysosomal,mitochondrial,manner,Moreover,localization,was,found,independent,autophagy,process,while,localized,triggered,apoptotic,event,upregulating,levels,reactive,oxygen,species,ROS,accelerate,fragmentation,This,work,uses,visualized,strategy,anti,tumor,bioactivity,which,achieved,apoptosis
AB值：
0.575677
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