Background:Liver recurrence after resection of colorectal liver metastases(CRLM)is frequent.Repeat hepatectomy has been shown to have satisfactory perioperative results.However,the long-term outcomes and the benefits for patients with early recurrence have not been clarified.The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM.Additionally,the oncological outcomes of patients with early(≤6 months)and late recurrence who underwent repeat hepatectomy were compared.Methods:Consecutive adult patients undergoing hepatectomy for CRLM between June 2000 and February 2020 were included and divided into two groups:single hepatectomy and repeat hepatectomy.Results:A total of 709 patients were included:649 in the single hepatectomy group and 60 in the repeat hepatectomy group.Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy[4(3-6)vs.3(2-4),P=0.003].Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5％vs.16.7％,P=0.004)and had a greater number of lesions re-sected(2.9±3.6 vs.1.9±1.8,P=0.011).There was no increase in operative time,estimated blood loss,length of hospital stay,complications,or mortality in the repeat hepatectomy group.There were no dif-ferences in overall survival(P=0.626)and disease-free survival(P=0.579)between the two groups.Similarly,for patients underwent repeat hepatectomy,no difference was observed between the early and late recurrence groups in terms of overall survival(P=0.771)or disease-free survival(P=0.350).Conclusions:Repeat hepatectomy is feasible and safe,with similar short-and long-term outcomes when compared to single hepatectomy.Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence.

Paulo Figueiredo Costa;Fabricio Ferreira Coelho;Vagner Birk Jeismann;Jaime Arthur Pirola Kruger;Gilton Marques Fonseca;Ivan Cecconello;Paulo Herman

Postgraduate Course in Digestive Surgery Brazilian College of Digestive Surgery(Colégio Brasileiro de Cirurgia Digestiva-CBCD),S?o Paulo,Brazil;Digestive Surgery Division,Department of Gastroenterology,University of S?o Paulo School of Medicine,S?o Paulo,Brazil;Instituto do Cancer do Estado de S?o Paulo(ICESP),S?o Paulo,Brazil

国际肝胆胰疾病杂志(英文版)

[1]Paulo Figueiredo Costa;Fabricio Ferreira Coelho;Vagner Birk Jeismann;Jaime Arthur Pirola Kruger;Gilton Marques Fonseca;Ivan Cecconello;Paulo Herman-.Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results)[J].国际肝胆胰疾病杂志(英文版),2022(02):162-167

hepatectomies,sected

Repeat,hepatectomy,recurrent,colorectal,liver,metastases,comparative,analysis,short,long,results,Background,Liver,recurrence,after,resection,CRLM,has,been,shown,have,satisfactory,perioperative,However,outcomes,benefits,patients,early,not,clarified,aim,this,study,was,undergoing,single,repeat,Additionally,oncological,months,late,who,underwent,were,compared,Methods,Consecutive,adult,between,June,February,included,divided,into,two,groups,Results,total,Patients,more,cycles,preoperative,chemotherapy,frequently,major,had,greater,number,lesions,There,increase,estimated,blood,loss,length,hospital,stay,complications,mortality,ferences,overall,survival,disease,free,Similarly,difference,observed,terms,Conclusions,feasible,safe,similar,when,Surgical,treatment,offers,those,obtained

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