Luminal androgen receptor (LAR) subtype of triple-negative breast cancer:molecular, morphological, and clinical features|Sergey VTORUSHIN;Anastasia DULESOVA;Nadezhda KRAKHMAL|Department of General and Molecular Pathology,Cancer Research Institute,Tomsk National Research Medical Center of the Russian Academy of Sciences,Tomsk 634009,Russia - 期刊导航|首站-论文投稿智能助手|论文发表|论文智能投稿|期刊自助发表推荐|杂志社快速发表|查同导刊-域田数据官方网站

典型文献

Luminal androgen receptor (LAR) subtype of triple-negative breast cancer:molecular, morphological, and clinical features

文献摘要：

According to the classification presented by Lehmann BD (2016), triple-negative breast cancer (TNBC) is a heterogeneous group of malignant tumors with four specific subtypes:basal-like (subtype 1 and subtype 2), mesenchymal, and luminal androgen receptor (LAR) subtypes. The basal-like subtypes of carcinomas predominate in this group, accounting for up to 80％ of all cases. Despite the significantly lower proportions of mesenchymal and LAR variants in the group of breast carcinomas with a TNBC profile, such tumors are characterized by aggressive biological behavior. To this end, the LAR subtype is of particular interest, since the literature on such tumors presents different and even contradictory data concerning the disease course and prognosis. This review is devoted to the analysis of the relevant literature, reflecting the main results of studies on the molecular properties and clinical features of the disease course of LAR-type TNBC carcinomas.

文献关键词：

中图分类号：

[1] 医药、卫生（R） / 肿瘤学（R73） / 泌尿生殖器肿瘤（R737） / 乳腺肿瘤（R737.9）

[2] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）

[3] 医药、卫生（R） / 基础医学（R3） / 病理学（R36） / 病理过程（R364）

作者姓名：

Sergey VTORUSHIN;Anastasia DULESOVA;Nadezhda KRAKHMAL

作者机构：

Department of Pathology,Siberian State Medical University Ministry of Health of Russia,Tomsk 634050,Russia;Department of General and Molecular Pathology,Cancer Research Institute,Tomsk National Research Medical Center of the Russian Academy of Sciences,Tomsk 634009,Russia;Department of Pathology,Republican Clinical Oncological Dispensary Ministry of Health,Tatarstan Republic,Kazan 420029,Russia

文献出处：

浙江大学学报（英文版）（B辑：生物医学和生物技术）

引用格式：

[1]Sergey VTORUSHIN;Anastasia DULESOVA;Nadezhda KRAKHMAL-.Luminal androgen receptor (LAR) subtype of triple-negative breast cancer:molecular, morphological, and clinical features)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(08):617-624

A类：

B类：

Luminal,androgen,receptor,LAR,triple,negative,breast,cancer,molecular,morphological,clinical,features,According,classification,presented,by,Lehmann,BD,TNBC,heterogeneous,group,malignant,tumors,four,specific,subtypes,basal,like,mesenchymal,luminal,carcinomas,predominate,this,accounting,all,cases,Despite,significantly,lower,proportions,variants,profile,such,are,characterized,aggressive,biological,behavior,To,end,particular,interest,since,literature,presents,different,even,contradictory,data,concerning,disease,course,prognosis,This,review,devoted,analysis,relevant,reflecting,main,results,studies,properties

AB值：

0.544339

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