Microneedle array(MNA)electrodes are an effective solution to achieve high-quality surface biopoten-tial recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications.Existing schemes are limited by flexibility,biosafety,and manufacturing costs,which create large barriers for wider applications.Here,we present a novel flexible MNA elec-trode that can simultaneously achieve flexibility of the sub-strate to fit a curved body surface,robustness of micronee-dles to penetrate the skin without fracture,and a simplified process to allow mass production.The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and con-venience of electrophysiological recording.The normalized electrode-skin contact impedance reaches 0.98 kΩ cm2 at 1 kHz and 1.50 kΩ cm2 at 10 Hz,a record low value compared to previous reports and approximately 1/250 of the standard electrodes.The morphology,biosafety,and electrical/mechanical properties are fully characterized,and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized.The first reported clini-cal study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording(over 8 h per night),providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.

Junshi Li;Yundong Ma;Dong Huang;Zhongyan Wang;Zhitong Zhang;Yingjie Ren;Mengyue Hong;Yufeng Chen;Tingyu Li;Xiaoyi Shi;Lu Cao;Jiayan Zhang;Bingli Jiao;Junhua Liu;Hongqiang Sun;Zhihong Li

National Key Laboratory of Science and Technology on Micro/Nano Fabrication,School of Integrated Circuits,Peking University,Beijing 100871,People's Republic of China;Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,People's Republic of China;School of Electronics,Peking University,Beijing 100871,People's Republic of China;Hypnometry Microsystem,Beijing 100871,People's Republic of China;College of Engineering,Peking University,Beijing 100871,People's Republic of China

纳微快报（英文）

[1]Junshi Li;Yundong Ma;Dong Huang;Zhongyan Wang;Zhitong Zhang;Yingjie Ren;Mengyue Hong;Yufeng Chen;Tingyu Li;Xiaoyi Shi;Lu Cao;Jiayan Zhang;Bingli Jiao;Junhua Liu;Hongqiang Sun;Zhihong Li-.High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography)[J].纳微快报（英文）,2022(08):142-163

Microneedle,Biopotential,Electrophysiological,biopoten,micronee,venience

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