典型文献
Jug-PLGA-NPs,a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma
文献摘要：
Objective:To verrify the anti-tumor efficacy and toxicity between juglone(Jug)and Jug-loaded poly lactic-co-glycolic acid(PLGA)nanoparticles(Jug-PLGA-NPs).Methods:Jug-PLGA-NPs were prepared by ultrasonic emulsification.The anti-tumor activity of Jug(2,3,4 μ g/mL)and Jug-PLGA-NPs(Jug:2,3,4 μ g/mL)in vitro was measured by MTT assay and cell apoptosis analysis.The distribution,anti-tumor effect and biological safety in vivo was evaluated on A375 nude mice.Results:With the advantage of good penetration and targeting properties,Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells both in vitro and in vivo(P＜0.05 or P＜0.01)with acceptable biocompatibility.Conclusions:Jug can inhibit the growth of melanoma but is highly toxic.With the advantage of sustained release,tumor targeting,anti-tumor activity and acceptable biological safety,Jug-PLGA-NPs provide a new pharmaceutical form for future application of Jug.
文献关键词：
中图分类号：
作者姓名：
YUE Wu-heng;QIN Lan-qun;CAI Juan;MEI Rui;QIAN Han-qing;ZOU Zheng-yun
作者机构：
The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Oncology,Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou,Jiangsu Province 215499,China;The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University,Nanjing 210008,China;The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital,Medical School of Nanjing University&Clinical Cancer Institute of Nanjing University,Nanjing 210008,China
文献出处：
引用格式：
[1]YUE Wu-heng;QIN Lan-qun;CAI Juan;MEI Rui;QIAN Han-qing;ZOU Zheng-yun-.Jug-PLGA-NPs,a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma)[J].中国结合医学杂志（英文版）,2022(10):909-917
A类：
Jug,Juglone,verrify,juglone
B类：
PLGA,NPs,New,Form,Enhanced,Efficiency,Reduced,Toxicity,Melanoma,Objective,anti,tumor,efficacy,toxicity,between,loaded,poly,lactic,glycolic,acid,nanoparticles,Methods,were,prepared,by,ultrasonic,emulsification,activity,vitro,was,measured,MTT,assay,apoptosis,analysis,distribution,effect,biological,safety,vivo,evaluated,A375,nude,mice,Results,With,advantage,good,penetration,targeting,properties,significantly,inhibited,proliferation,migration,melanoma,cells,both,acceptable,biocompatibility,Conclusions,growth,highly,sustained,release,provide,new,pharmaceutical,form,future,application
AB值：
0.470681
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