典型文献
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond
文献摘要：
Malignant melanoma Is accounting for most of skin cancer-associated mortality.The incidence of melanoma increased every year worldwide especially In western countries,Treatment efficiency is highly related to the stage of melanoma.Therefore,accurate staging and restaging play a pivotal role in the management of melanoma patients.Though 18F-fluorodeoxyglucose(18F-FDG)positron-emission tomography(PET)has been widely used in imaging of tumor metastases,novel radioactive probes for specific targeted imaging of both primary and metastasized melanoma are still desired.Melanocortin receptor 1(MC1R)and melanin are two promising biomarkers specifically for melanoma,and numerous research groups Including us have been actively developing a plethora of radioactive probes based on targeting of MC1R or melanin for over two decades.In this review,some of the MC1R-targeted tracers and melanin-associated molecular imaging probes developed In our research and others have been briefly summarized,and It provides a quick glance of melanoma-targeted probe design and may contribute to further developing novel molecular probes for cancer theranostics.
文献关键词：
中图分类号：
作者姓名：
Hui Shi;Zhen Cheng
作者机构：
State Key Laboratory of Drug Research,Molecular Imaging Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,No.19A Yuquan Road,Beijing 100049,China;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai 264117,China
文献出处：
引用格式：
[1]Hui Shi;Zhen Cheng-.MC1R and melanin-based molecular probes for theranostic of melanoma and beyond)[J].中国药理学报（英文版）,2022(12):3034-3044
A类：
restaging,metastasized,Melanocortin,glance
B类：
MC1R,melanin,molecular,probes,melanoma,beyond,Malignant,Is,accounting,most,skin,cancer,associated,mortality,incidence,increased,every,year,worldwide,especially,western,countries,Treatment,efficiency,highly,related,stage,Therefore,accurate,play,pivotal,role,management,patients,Though,18F,fluorodeoxyglucose,FDG,positron,emission,tomography,PET,has,been,widely,used,imaging,tumor,metastases,novel,radioactive,targeted,both,primary,are,still,desired,receptor,two,promising,biomarkers,specifically,numerous,research,groups,Including,have,actively,developing,plethora,targeting,over,decades,this,review,some,tracers,developed,our,others,briefly,summarized,It,provides,quick,design,may,contribute,further,theranostics
AB值：
0.554055
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