典型文献
Interleukins in the treatment of melanoma
文献摘要：
Interleukins (ILs) and associated cytokines serve as the means of communication for immune cells and non-immune cells. The use of ILs in harnessing the immune system to cancer treatment has been a promising approach. ILs not only nurture an environment enabling cancer growth but also simultaneously trigger a productive tumor-directed immune response. These properties of ILs are increasingly being explored as a strategy to improve the outcomes of cancer. Here, we describe recently innovative technological approaches that have been developed to improve the pharmacokinetics, safety, and efficacies of IL-2, 15, 10, and 18 in the treatment of melanoma. Furthermore, the combination of ILs and immune checkpoint inhibition may synergize to reshape the tumor environment, thus yielding better clinical benefits in the future.
文献关键词：
IL-2;IL-15;IL-10;IL-18;Melanoma;Immunotherapy
中图分类号：
作者姓名：
Xu Xinyuan;Dai Wei;Li Chunying
作者机构：
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
文献出处：
引用格式：
[1]Xu Xinyuan;Dai Wei;Li Chunying-.Interleukins in the treatment of melanoma)[J].中华医学杂志（英文版）,2022(04):393-399
A类：
Interleukins
B类：
treatment,melanoma,ILs,associated,cytokines,serve,means,communication,immune,cells,use,harnessing,system,cancer,has,been,promising,only,nurture,environment,enabling,growth,but,also,simultaneously,trigger,productive,tumor,directed,response,These,properties,are,increasingly,being,explored,strategy,improve,outcomes,Here,we,describe,recently,innovative,technological,approaches,that,have,developed,pharmacokinetics,safety,efficacies,Furthermore,combination,checkpoint,inhibition,may,synergize,reshape,thus,yielding,better,clinical,benefits,future,Melanoma,Immunotherapy
AB值：
0.617285
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