典型文献
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
文献摘要：
Chronic stress impairs radial neural stem cell(rNSC)differentiation and adult hippocampal neurogenesis(AHN),whereas promoting AHN can increase stress resilience against depression.Therefore,investigating the mechanism of neural differentiation and AHN is of great importance for developing antidepressant drugs.The nonpsychoactive phytocannabinoid cannabidiol(CBD)has been shown to be effective against depression.However,whether CBD can modulate rNSC differentiation and hippocampal neurogenesis is unknown.Here,by using the chronic restraint stress(CRS)mouse model,we showed that hippocampal rNSCs mostly differentiated into astrocytes under stress conditions.Moreover,transcriptome analysis revealed that the FoxO signaling pathway was involved in the regulation of this process.The administration of CBD rescued depressive-like symptoms in CRS mice and prevented rNSCs overactivation and differentiation into astrocyte,which was partly mediated by the modulation of the FoxO signaling pathway.These results revealed a previously unknown neural mechanism for neural differentiation and AHN in depression and provided mechanistic insights into the antidepressive effects of CBD.
文献关键词：
中图分类号：
作者姓名：
Ming Hou;Suji Wang;Dandan Yu;Xinyi Lu;Xiansen Zhao;Zhangpeng Chen;Chao Yan
作者机构：
State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210023,China;Institute of Artificial Intelligence Biomedicine,Nanjing University,Nanjing 210023,China;Chemistry and Biomedicine Innovation Center Nanjing University,Nanjing 210023,China;Engineering Research Center of Protein and Peptide Medicine,Ministry of Education,Nanjing 210023,China
文献出处：
引用格式：
[1]Ming Hou;Suji Wang;Dandan Yu;Xinyi Lu;Xiansen Zhao;Zhangpeng Chen;Chao Yan-.Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation)[J].医学前沿,2022(02):227-239
A类：
rNSC,nonpsychoactive,phytocannabinoid,rNSCs,antidepressive
B类：
Cannabidiol,prevents,like,behaviors,through,modulation,neural,stem,cell,differentiation,Chronic,stress,impairs,radial,adult,hippocampal,neurogenesis,AHN,whereas,promoting,increase,resilience,against,depression,Therefore,investigating,mechanism,great,importance,developing,antidepressant,drugs,cannabidiol,CBD,has,been,shown,effective,However,whether,modulate,unknown,Here,by,using,chronic,restraint,CRS,mouse,model,showed,that,mostly,differentiated,into,astrocytes,under,conditions,Moreover,transcriptome,analysis,revealed,FoxO,signaling,pathway,was,involved,regulation,this,process,administration,rescued,symptoms,mice,prevented,overactivation,which,partly,mediated,These,results,previously,provided,mechanistic,insights,effects
AB值：
0.534934
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
