典型文献
UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis
文献摘要：
Up-frameshift 1 (UPF1), as the most critical factor in nonsense-mediated messenger RNA (mRNA) decay (NMD), regulates tumor-associated molecular pathways in many cancers. However, the role of UPF1 in lung adenocarcinoma (LUAD) amino acid metabolism remains largely unknown. In this study, we found that UPF1 was significantly correlated with a portion of amino acid metabolic pathways in LUAD by integrating bioinformatics and metabolomics. We further confirmed that UPF1 knockdown inhibited activating transcription factor 4 (ATF4) and Ser51 phosphorylation of eukaryotic translation initiation factor 2α(eIF2α), the core proteins in amino acid metabolism reprogramming. In addition, UPF1 promotes cell proliferation by increasing the amino-acid levels of LUAD cells, which depends on the function of ATF4. Clinically, UPF1 mRNA expression is abnormal in LUAD tissues, and higher expression of UPF1 and ATF4 was significantly correlated with poor overall survival (OS) in LUAD patients. Our findings reveal that UPF1 is a potential regulator of tumor-associated amino acid metabolism and may be a therapeutic target for LUAD.
文献关键词：
中图分类号：
作者姓名：
Lei FANG;Huan QI;Peng WANG;Shiqing WANG;Tianjiao LI;Tian XIA;Hailong PIAO;Chundong GU
作者机构：
Department of Thoracic Surgery,Lung Cancer Diagnosis and Treatment Center of Dalian,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China
引用格式：
[1]Lei FANG;Huan QI;Peng WANG;Shiqing WANG;Tianjiao LI;Tian XIA;Hailong PIAO;Chundong GU-.UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(10):863-875
A类：
Ser51
B类：
UPF1,increases,amino,acid,levels,promotes,proliferation,lung,adenocarcinoma,via,eIF2,ATF4,axis,Up,frameshift,most,critical,nonsense,mediated,messenger,decay,NMD,regulates,tumor,associated,molecular,pathways,many,cancers,However,role,LUAD,metabolism,remains,largely,unknown,In,this,study,found,that,was,significantly,correlated,portion,metabolic,by,integrating,bioinformatics,metabolomics,We,further,confirmed,knockdown,inhibited,activating,transcription,phosphorylation,eukaryotic,translation,initiation,core,proteins,reprogramming,addition,increasing,cells,which,depends,function,Clinically,expression,abnormal,tissues,higher,poor,overall,survival,OS,patients,Our,findings,reveal,potential,regulator,may,be,therapeutic,target
AB值：
0.547342
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
