典型文献
Qi-Tai-Suan,an oleanolic acid derivative,ameliorates ischemic heart failure via suppression of cardiac apoptosis,inflammation and fibrosis
文献摘要：
Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction(MI),by far,there are few preventive and therapeutic options for ischemic heart failure(IHF)after MI.Qi-Tai-Suan(QTS)is an oleanolic acid(OA)derivative which once underwent a clinical trial for treating hepatitis.In this study,we investigated the potential cardiopro-tective effect of QTS on IHF.IHF mouse model was constructed by coronary artery ligation in male C57BL/6J mice,and the protect-ive effects of QTS on IHF were examined by echocardiography measurement,histological and TUNEL analysis,etc.We found that QTS exhibited promising cardioprotective effect on IHF.QTS treatment significantly improved cardiac function of IHF mice and the symptoms of heart failure.Notably,QTS had much better oral bioavailability(F=41.91％)in mice than its parent drug OA,and took effects mainly as its original form.Mechanistically,QTS ameliorated ischemic heart failure likely through suppression of cardiac apop-tosis,inflammation and fibrosis.Taken together,QTS holds great promise as a preventive and therapeutic agent for ischemic heart fail-ure and related diseases.
文献关键词：
中图分类号：
作者姓名：
QIAN Ming;FENG Zhi-Qi;ZHENG Ru-Nan;HU Kai-Wen;SUN Jia-Ze;SUN Hong-Bin;DAI Liang
作者机构：
Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease,State Key Laboratory of Natural Medicines,China Pharma-ceutical University,Nanjing 210009,China
文献出处：
引用格式：
[1]QIAN Ming;FENG Zhi-Qi;ZHENG Ru-Nan;HU Kai-Wen;SUN Jia-Ze;SUN Hong-Bin;DAI Liang-.Qi-Tai-Suan,an oleanolic acid derivative,ameliorates ischemic heart failure via suppression of cardiac apoptosis,inflammation and fibrosis)[J].中国天然药物,2022(06):432-442
A类：
Suan,QTS,cardiopro,apop
B类：
Qi,Tai,oleanolic,acid,derivative,ameliorates,ischemic,heart,failure,via,suppression,cardiac,apoptosis,inflammation,fibrosis,Although,anti,thrombotic,therapy,has,been,successful,prevention,deaths,from,acute,myocardial,infarction,MI,by,there,few,preventive,therapeutic,options,IHF,after,OA,which,once,underwent,clinical,trial,treating,hepatitis,In,this,study,investigated,potential,mouse,model,was,constructed,coronary,artery,ligation,male,C57BL,6J,mice,effects,were,examined,echocardiography,measurement,histological,TUNEL,analysis,etc,We,found,that,exhibited,promising,cardioprotective,treatment,significantly,improved,function,symptoms,Notably,had,much,better,oral,bioavailability,than,its,parent,drug,took,mainly,original,form,Mechanistically,ameliorated,likely,through,Taken,together,holds,great,promise,agent,related,diseases
AB值：
0.53491
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
