典型文献
Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling
文献摘要：
Insufficient remyelination due to impaired oligo-dendrocyte precursor cell(OPC)differentiation and matu-ration is strongly associated with irreversible white mat-ter injury(WMI)and neurological deficits.We analyzed whole transcriptome expression to elucidate the potential role and underlying mechanism of action of lipocalin-2(LCN2)in OPC differentiation and WMI and identified the receptor SCL22A17 and downstream transcription factor early growth response protein 1(EGR1)as the key signals contributing to LCN2-mediated insufficient OPC remyeli-nation.In LCN-knockdown and OPC EGR1 conditional-knockout mice,we discovered enhanced OPC differentiation in developing and injured white matter(WM);consistent with this,the specific inactivation of LCN2/SC122A17/EGR1 signaling promoted remyelination and neurological recovery in both atypical,acute WMI due to subarachnoid hemorrhage and typical,chronic WMI due to multiple scle-rosis.This potentially represents a novel strategy to enhance differentiation and remyelination in patients with white mat-ter injury.
文献关键词：
中图分类号：
作者姓名：
Qiang Li;Xufang Ru;Yang Yang;Hengli Zhao;Jie Qu;Weixiang Chen;Pengyu Pan;Huaizhen Ruan;Chaojun Li;Yujie Chen;Hua Feng
作者机构：
Department of Neurosurgery and State Key Laboratory of Trauma,Burn and Combined Injury,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China;Department of Neurobiology,College of Basic Medical Sciences,Third Military Medical University(Army Medical University),Chongqing 400038,China;Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China;Chongqing Clinical Research Center for Neurosurgery,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China;Model Animal Research Center,Nanjing University,Nanjing 210032,China
文献出处：
引用格式：
[1]Qiang Li;Xufang Ru;Yang Yang;Hengli Zhao;Jie Qu;Weixiang Chen;Pengyu Pan;Huaizhen Ruan;Chaojun Li;Yujie Chen;Hua Feng-.Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling)[J].神经科学通报（英文版）,2022(12):1457-1475
A类：
Oligodendrocyte,Remyelination,SCL22A17,dendrocyte,remyeli,SC122A17
B类：
Lipocalin,Mediated,Insufficient,Progenitor,Cell,White,Matter,Injury,After,Subarachnoid,Hemorrhage,via,Receptor,Early,Growth,Response,Protein,Signaling,remyelination,due,impaired,oligo,precursor,cell,OPC,differentiation,matu,ration,strongly,associated,irreversible,white,injury,WMI,neurological,deficits,We,analyzed,whole,transcriptome,expression,elucidate,role,underlying,mechanism,action,lipocalin,LCN2,identified,receptor,downstream,transcription,early,growth,response,protein,EGR1,key,signals,contributing,mediated,insufficient,knockdown,conditional,knockout,mice,we,discovered,enhanced,developing,injured,matter,consistent,this,specific,inactivation,signaling,promoted,recovery,both,atypical,acute,subarachnoid,hemorrhage,chronic,multiple,scle,rosis,This,potentially,represents,novel,strategy,patients
AB值：
0.586812
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
