典型文献
Precise electro-reduction of alkyl halides for radical defluorinative alkylation
文献摘要：
Reported here is a precise electro-reduction strategy for radical defluorinative alkylation towards the synthesis of gem-di-fluoroalkenes from α-trifluoromethylstyrenes.According to the redox-potential difference of the radical precursors,direct or indirect electrolysis is respectively adopted to realize the precise reduction.An easy-to-handle,catalyst-and metal-free condition is developed for the reduction of alkyl radical precursors that are generally easier to be reduced than α-trifluoromethylstyrenes,while a novel electro-Ni-catalytic system is established for the electro-reduction of alkyl bromides or chlorides towards the electrochemical synthesis of gem-difluoroalkenes.The merit of this protocol is exhibited by its mild conditions,wide substrate scope,and scalable preparation.Mechanistic studies and DFT calculations proved that the coordination of α-tri-fluoromethylstyrenes to Ni-catalyst prevents the direct reduction of the alkene and,in turn,promotes the activation of alkyl bromide through halogen atom transfer mechanism.
文献关键词：
中图分类号：
作者姓名：
Xingxiu Yan;Shengchun Wang;Zhao Liu;Yujie Luo;Pengjie Wang;Wenyan Shi;Xiaotian Qi;Zhiliang Huang;Aiwen Lei
作者机构：
Institute for Advanced Studies(IAS)and College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China
文献出处：
引用格式：
[1]Xingxiu Yan;Shengchun Wang;Zhao Liu;Yujie Luo;Pengjie Wang;Wenyan Shi;Xiaotian Qi;Zhiliang Huang;Aiwen Lei-.Precise electro-reduction of alkyl halides for radical defluorinative alkylation)[J].中国科学:化学（英文版）,2022(04):762-770
A类：
fluoroalkenes,trifluoromethylstyrenes,fluoromethylstyrenes
B类：
Precise,reduction,halides,radical,defluorinative,alkylation,Reported,here,precise,strategy,towards,synthesis,gem,from,According,redox,potential,difference,precursors,indirect,electrolysis,respectively,adopted,realize,An,easy,handle,catalyst,metal,free,developed,that,are,generally,easier,be,reduced,than,while,novel,catalytic,system,established,bromides,chlorides,electrochemical,difluoroalkenes,merit,this,protocol,exhibited,by,its,mild,conditions,wide,substrate,scope,scalable,preparation,Mechanistic,studies,DFT,calculations,proved,coordination,prevents,turn,promotes,activation,through,halogen,atom,transfer,mechanism
AB值：
0.545223
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
