典型文献
Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils
文献摘要：
The deposition of highly ordered amyloid fibrils is recognized as a hallmark of amyloidosis diseases such as Alzheimer's disease and Parkinson's disease.Disaggregating the amyloid fibrils is considered as one of the effective strategies for the control and treatment of amyloidosis diseases.In this article,by simulating the function of natural molecular chaperones,co-assembled block copolymer micelles with coordination groups of nitrilotriacetic acid(NTA)and hydrophobic microdomains of poly(N-isopropylacrylamide)(PNIPAM)on the surface were used as nanochaperones(nChaps)to disaggregate amyloid insulin fibrils.Zinc ions chelated by NTA can bind the histidine imidazole residues while the PNIPAM microdomains can interact with the exposed hydrophobic sites on the amyloid insulin fibrils,which synergistically perturb the stability of amyloid insulin fibrils,loosen their structure,and finally promote their disaggregation.A combination of characterizations with fluorescence spec-troscopy,transmission electron microscopy(TEM),dynamic hight scattering(DLS),and quartz crystal microbalance(QCM)demonstrated that mature amyloid insulin fibrils were completely disaggregated after incubating with nChaps for 90 h.This study may provide a promising strategy for the development of nChaps for the treatment of amyloidosis diseases.
文献关键词：
中图分类号：
作者姓名：
Hui Wang;Ang Li;Menglin Yang;Yu Zhao;Linqi Shi;Rujiang Ma
作者机构：
Key Laboratory of Functional Polymer Materials of Ministry of Education,Institute of Polymer Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China;State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin 300071,China
文献出处：
引用格式：
[1]Hui Wang;Ang Li;Menglin Yang;Yu Zhao;Linqi Shi;Rujiang Ma-.Self-assembled nanochaperones enable the disaggregation of amyloid insulin fibrils)[J].中国科学:化学（英文版）,2022(02):353-362
A类：
nanochaperones,Disaggregating,nChaps,disaggregate,loosen,hight,disaggregated
B类：
Self,assembled,enable,disaggregation,insulin,fibrils,deposition,highly,ordered,recognized,hallmark,amyloidosis,diseases,such,Alzheimer,Parkinson,considered,effective,strategies,control,treatment,In,this,article,by,simulating,function,natural,molecular,block,copolymer,micelles,coordination,groups,nitrilotriacetic,acid,NTA,hydrophobic,microdomains,isopropylacrylamide,PNIPAM,surface,were,used,Zinc,chelated,can,bind,histidine,imidazole,residues,while,interact,exposed,sites,which,synergistically,perturb,stability,their,structure,finally,promote,combination,characterizations,fluorescence,spec,troscopy,transmission,electron,microscopy,TEM,dynamic,scattering,DLS,quartz,crystal,microbalance,QCM,demonstrated,that,mature,completely,after,incubating,This,study,may,provide,promising,strategy,development
AB值：
0.52761
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