典型文献
68Ga-PSMA ligand PET/CT integrating indocyanine green-guided salvage lymph node dissection for lymph node metastasis after radical prostatectomy
文献摘要：
To efficiently remove all recurrent lymph nodes(rLNs)and minimize complications,we developed a combination approach that consisted of 68Gallium prostate-specific membrane antigen(PSMA)ligand positron emission tomography(PET)/computed tomography(CT)and integrated indocyanine green(ICG)-guided salvage lymph node dissection(sLND)for rLNs after radical prostatectomy(RP).Nineteen patients were enrolled to receive such treatment.68Ga-PSMA ligand PET/CT was used to identify rLNs,and 5 mg of ICG was injected into the space between the rectum and bladder before surgery.Fluorescent laparoscopy was used to perform sLND.While extensive LN dissection was performed at level I,another 5 mg of ICG was injected via the intravenous route to intensify the fluorescent signal,and laparoscopy was introduced to intensively target stained LNs along levels Ⅰ and Ⅱ,specifically around suspicious LNs,with 68Ga-PSMA ligand PET/CT.Next,both lateral peritonea were exposed longitudinally to facilitate the removal of fluorescently stained LNs at levels Ⅲ and Ⅳ.In total,pathological analysis confirmed that 42 nodes were rLNs.Among 145 positive LNs stained with ICG,24 suspicious LNs identified with 68Ga-PSMA ligand PET/CT were included.The sensitivity and specificity of 68Ga-PSMA ligand PET/CT for detecting rLNs were 42.9％and 96.6％,respectively.For ICG,the sensitivity was 92.8％and the specificity was 39.1％.At a median follow-up of 15(interquartile range[IQR]:6-31)months,15 patients experienced complete biochemical remission(BR,prostate-specific antigen[PSA]＜0.2 ng ml-1),and 4 patients had a decline in the PSA level,but it remained＞0.2 ng ml-1.Therefore,"Ga-PSMA ligand PET/CT integrating ICG-guided sLND provides efficient sLND with few complications for patients with rLNs after RP.
文献关键词：
中图分类号：
作者姓名：
Teng-Cheng Li;Yu Wang;Chu-Tian Xiao;Ming-Zhao Li;Xiao-Peng Liu;Wen-Tao Huang;Liao-Yuan Li;Ke Li;Jin-Ming Di;Xing-Qiao Wen;Xin Gao
作者机构：
Department of Urology,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China
文献出处：
引用格式：
[1]Teng-Cheng Li;Yu Wang;Chu-Tian Xiao;Ming-Zhao Li;Xiao-Peng Liu;Wen-Tao Huang;Liao-Yuan Li;Ke Li;Jin-Ming Di;Xing-Qiao Wen;Xin Gao-.68Ga-PSMA ligand PET/CT integrating indocyanine green-guided salvage lymph node dissection for lymph node metastasis after radical prostatectomy)[J].亚洲男性学杂志（英文版）,2022(01):97-101
A类：
rLNs,68Gallium,sLND,peritonea
B类：
PSMA,ligand,PET,integrating,indocyanine,green,guided,salvage,lymph,dissection,metastasis,after,radical,prostatectomy,To,efficiently,remove,recurrent,nodes,minimize,complications,developed,combination,approach,that,consisted,membrane,antigen,positron,tomography,computed,integrated,ICG,RP,Nineteen,patients,were,enrolled,receive,such,treatment,was,used,identify,injected,into,space,between,rectum,bladder,before,surgery,Fluorescent,laparoscopy,While,extensive,performed,another,via,intravenous,route,intensify,signal,introduced,intensively,target,stained,along,levels,specifically,around,suspicious,Next,both,lateral,exposed,longitudinally,facilitate,removal,fluorescently,In,total,pathological,analysis,confirmed,Among,positive,identified,included,sensitivity,specificity,detecting,respectively,For,At,median,follow,up,interquartile,range,IQR,months,experienced,complete,biochemical,remission,BR,PSA,ml,had,decline,but,remained,Therefore,provides,few
AB值：
0.438559
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