典型文献
A SNIPpet of safety:a Goldilocks approach in CAR-T therapy
文献摘要：
Despite the remarkable efficacy of chimeric antigen receptor(CAR)T-cells in B-cell malignancies,their full potential in solid tumors has not yet been achieved.In a recent publication in Cell,Labanieh et al.developed a druggable CAR T-cell construct that allows optimal fine-tuning of CAR T-cells to achieve maximal efficacy and reduce toxicity.
With the advent of CD19 targeting using chimeric antigen receptor(CAR)T-cells,the potential of immunotherapy,in particular adoptive cell therapy,became a reality.CD19-directed CAR T-cells have been transformative-eradicating disease in the most chemotherapy-refractory patients,with potential to induce long-term durable remissions.While inflammatory toxicities related to T-cell expansion can be life-threatening,the iterative recognition of and approach to treatment of cytokine release syndrome(CRS)and sequelae thereof,along with the development of pre-emptive interventions and supportive care measures,1 facilitated the safe implementation across patient populations.Additionally,the tolerance for on-target,off-tumor targeting enabled implementation of a therapeutic approach where broad antigen targeting was not of substantial concern.
文献关键词：
中图分类号：
作者姓名：
Mehdi Benzaoui;Naomi Taylor;Nirali N.Shah
作者机构：
Pediatric Oncology Branch,Center for Cancer Research,National Cancer Institute,National Institutes of Health,Bethesda,MD,USA;Institut de Génétique Moléculaire de Montpellier,Univ Montpellier,CNRS,Montpellier,France
文献出处：
引用格式：
[1]Mehdi Benzaoui;Naomi Taylor;Nirali N.Shah-.A SNIPpet of safety:a Goldilocks approach in CAR-T therapy)[J].细胞研究（英文版）,2022(07):603-604
A类：
SNIPpet,Labanieh,remissions
B类：
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With,advent,CD19,targeting,using,immunotherapy,particular,adoptive,became,reality,directed,have,transformative,eradicating,disease,most,chemotherapy,refractory,patients,induce,term,durable,While,inflammatory,toxicities,related,expansion,can,life,threatening,iterative,recognition,treatment,cytokine,release,syndrome,CRS,sequelae,thereof,along,development,pre,emptive,interventions,supportive,care,measures,facilitated,implementation,across,populations,Additionally,tolerance,off,enabled,therapeutic,where,broad,was,substantial,concern
AB值：
0.650763
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