典型文献
Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity
文献摘要：
As a first-line treatment,radiotherapy(RT)is known to modulate the immune microenvironment of glioma,but it is unknown whether the meningeal lymphatic vessel(MLV)-cervical lymph node(CLN)network regulates the process or influences RT efficacy.Here,we show that the MLV-CLN network contributes to RT efficacy in brain tumors and mediates the RT-modulated anti-tumor immunity that is enhanced by vascular endothelial growth factor C(VEGF-C).Meningeal lymphatic dysfunction impaired tumor-derived dendritic cell(DC)trafficking and CD8+T cell activation after RT,whereas tumors overexpressing VEGF-C with meningeal lymphatic expansion were highly sensitive to RT.Mechanistically,VEGF-C-driven modulation of RT-triggered anti-tumor immunity was attributed to C-C Motif Chemokine Ligand 21(CCL21)-dependent DC trafficking and CD8+T cell activation.Notably,delivery of VEGF-C mRNA significantly enhanced RT efficacy and anti-tumor immunity in brain tumors.These findings suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity,and highlight the potential of VEGF-C mRNA for brain tumor therapy.
文献关键词：
中图分类号：
作者姓名：
Changping Zhou;Lu Ma;Han Xu;Yingqing Huo;Jincai Luo
作者机构：
Laboratory of Vascular Biology,Institute of Molecular Medicine,College of Future Technology,Beijing Key Laboratory of Cardiometabolic Molecular Medicine,Peking University,Beijing,China
文献出处：
引用格式：
[1]Changping Zhou;Lu Ma;Han Xu;Yingqing Huo;Jincai Luo-.Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity)[J].细胞研究（英文版）,2022(06):543-554
A类：
Meningeal,lymphatics
B类：
radiotherapy,efficacy,through,modulating,anti,immunity,first,line,treatment,immune,microenvironment,glioma,unknown,whether,meningeal,vessel,MLV,cervical,node,CLN,network,regulates,process,influences,Here,show,that,contributes,brain,tumors,mediates,modulated,enhanced,by,vascular,endothelial,growth,VEGF,dysfunction,impaired,derived,dendritic,cell,DC,trafficking,CD8+T,activation,after,whereas,overexpressing,expansion,were,highly,sensitive,Mechanistically,driven,modulation,triggered,was,attributed,Motif,Chemokine,Ligand,CCL21,dependent,Notably,delivery,significantly,These,findings,suggest,essential,role,highlight,potential
AB值：
0.485527
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