典型文献
Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
文献摘要：
Nuclear pore complex(NPC)shuttles cargo across the nuclear envelope.Here we present single-particle cryo-EM structure of the nuclear ring(NR)subunit from Xenopus laevis NPC at an average resolution of 5.6 ?.The NR subunit comprises two 10-membered Y complexes,each with the nucleoporin ELYS closely associating with Nup160 and Nup37 of the long arm.Unlike the cytoplasmic ring(CR)or inner ring(IR),the NR subunit contains only one molecule each of Nup205 and Nup93.Nup205 binds both arms of the Y complexes and interacts with the stem of inner Y complex from the neighboring subunit.Nup93 connects the stems of inner and outer Y complexes within the same NR subunit,and places its N-terminal extended helix into the axial groove of Nup205 from the neighboring subunit.Together with other structural information,we have generated a composite atomic model of the central ring scaffold that includes the NR,IR,and CR.The IR is connected to the two outer rings mainly through Nup155.This model facilitates functional understanding of vertebrate NPC.
文献关键词：
中图分类号：
作者姓名：
Gaoxingyu Huang;Xiechao Zhan;Chao Zeng;Xuechen Zhu;Ke Liang;Yanyu Zhao;Pan Wang;Qifan Wang;Qiang Zhou;Qinghua Tao;Minhao Liu;Jianlin Lei;Chuangye Yan;Yigong Shi
作者机构：
Westlake Laboratory of Life Sciences and Biomedicine,18 Shilongshan Road,Hangzhou,Zhejiang,China;Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,18 Shilongshan Road,Hangzhou,Zhejiang,China;Institute of Biology,Westlake Institute for Advanced Study,18 Shilongshan Road,Hangzhou,Zhejiang,China;Beijing Advanced Innovation Center for Structural Biology&Frontier Research Center for Biological Structure,Tsinghua University,Beijing,China;Tsinghua University-Peking University Joint Center for Life Sciences;School of Life Sciences,Tsinghua University,Beijing,China
文献出处：
引用格式：
[1]Gaoxingyu Huang;Xiechao Zhan;Chao Zeng;Xuechen Zhu;Ke Liang;Yanyu Zhao;Pan Wang;Qifan Wang;Qiang Zhou;Qinghua Tao;Minhao Liu;Jianlin Lei;Chuangye Yan;Yigong Shi-.Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex)[J].细胞研究（英文版）,2022(04):349-358
A类：
nucleoporin,ELYS,Nup160,Nup37,Nup205,Nup93,Nup155
B类：
Cryo,EM,structure,nuclear,from,Xenopus,laevis,pore,Nuclear,NPC,shuttles,cargo,across,envelope,Here,we,present,single,particle,cryo,NR,subunit,average,resolution,comprises,two,membered,complexes,each,closely,associating,long,Unlike,cytoplasmic,CR,inner,contains,only,one,molecule,binds,both,arms,interacts,neighboring,connects,stems,outer,within,same,places,its,terminal,extended,helix,into,axial,groove,Together,other,structural,information,have,generated,composite,atomic,model,central,scaffold,that,includes,connected,rings,mainly,through,This,facilitates,functional,understanding,vertebrate
AB值：
0.501544
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
