典型文献
The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis
文献摘要：
Although two Enhancer of Polycomb-like proteins, EPL1A and EPL1B (EPL1A/B), are known to be conserved and characteristic subunits of the NuA4-type histone acetyltransferase complex in Arabidopsis thaliana, the biological function of EPL1A/B and the mechanism by which EPL1A/B function in the complex remain unknown. Here, we report that EPL1A/B are required for the histone acetyltransferase activity of the NuA4 complex on the nucleosomal histone H4 in vitro and for the enrichment of histone H4K5 acetylation at thousands of protein-coding genes in vivo. Our results suggest that EPL1A/B are required for linking the NuA4 catalytic subunits HISTONE ACETYLTRANSFERASE OF THE MYST FAMILY 1 (HAM1) and HAM2 with accessory subunits in the NuA4 complex. EPL1A/B function redundantly in regulating plant development especially in chlorophyll biosynthesis and de-etiolation. The EPL1A/B-dependent transcription and H4K5Ac are enriched at genes involved in chlorophyll bio-synthesis and photosynthesis. We also find that EAF6, another characteristic subunit of the NuA4 complex, contributes to de-etiolation. These re-sults suggest that the Arabidopsis NuA4 complex components function as a whole to mediate his-tone acetylation and transcriptional activation specifically at light-responsive genes and are critical for photomorphogenesis.
文献关键词：
中图分类号：
作者姓名：
Jin-Xing Zhou;Xiao-Min Su;Si-Yao Zheng;Chan-Juan Wu;Yin-Na Su;Zhaodi Jiang;Lin Li;She Chen;Xin-Jian He
作者机构：
College of Life Sciences,Beijing Normal University,Beijing 100091,China;National Institute of Biological Sciences,Beijing 102206,China;Tsinghua Institute of Multidisciplinary Biomedical Research,Tsinghua University,Beijing 100084,China
文献出处：
引用格式：
[1]Jin-Xing Zhou;Xiao-Min Su;Si-Yao Zheng;Chan-Juan Wu;Yin-Na Su;Zhaodi Jiang;Lin Li;She Chen;Xin-Jian He-.The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis)[J].植物学报（英文版）,2022(04):901-914
A类：
NuA4,EPL1A,EPL1B,nucleosomal,H4K5,HISTONE,ACETYLTRANSFERASE,HAM1,HAM2,etiolation,H4K5Ac,EAF6,photomorphogenesis
B类：
Arabidopsis,histone,acetyltransferase,complex,required,chlorophyll,biosynthesis,photosynthesis,Although,two,Enhancer,Polycomb,like,proteins,are,be,conserved,characteristic,subunits,type,thaliana,biological,function,mechanism,by,which,remain,unknown,Here,we,report,that,activity,vitro,enrichment,acetylation,thousands,coding,vivo,Our,results,suggest,linking,catalytic,OF,THE,MYST,FAMILY,accessory,redundantly,regulating,plant,development,especially,dependent,enriched,involved,We,also,find,another,contributes,These,components,whole,mediate,transcriptional,activation,specifically,light,responsive,critical
AB值：
0.362232
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
