典型文献
Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs
文献摘要：
Delving into porcine embryonic myogenesis is the key to elucidate the complex regulation of breed-specific dif-ferences in growth performance and meat production.Increasing evidence proves that pigs with less meat pro-duction show earlier embryonic myogenesis,but little is known about the underlying mechanisms.In this study,we examine the longissimus dorsi muscle(LDM)by immunohistochemistry and confirm that the differentiation of myogenic progenitors is increased(P＜0.05)in Lantang(LT,fatty)pigs compared with that in Landrace(LR,lean)pigs,which results in more(P＜0.001)differentiated myoblasts(Pax7-/MyoD+)and less(P＜0.001)myogenic pro-genitors(Pax7+/MyoD-)in LT pigs at 35 days post-conception(35dpc).Additionally,embryonic myogenic pro-genitors isolated from LT pigs show greater(P＜0.001)differentiation capacity with earlier expression of MyoD compared with those from LR pigs.Moreover,Notch signaling is more active(P＜0.05)in LR pig myogenic pro-genitors than in LT pig myogenic progenitors.Inhibition of Notch signaling in LR myogenic progenitors suppresses Pax7 expression and increases MyoD expression,thus promoting myogenic differentiation.Consistently,the process of myogenic progenitors differentiating into myoblasts in ex vivo embryo limbs is accelerated when Notch signaling is inhibited.These results indicate that Notch signaling facilitates the maintenance of myogenic pro-genitors and antagonizes myogenic differentiation by promoting Pax7 expression and preventing MyoD expression in LR pigs.
文献关键词：
中图分类号：
作者姓名：
Shufang Cai;Bin Hu;Qi Zhu;Tianqi Duo;Xiaoyu Wang;Xian Tong;Xiaorong Luo;Renqiang Yuan;Yaosheng Chen;Jing Wang;Chenglong Luo;Baosong Xing;Delin Mo
作者机构：
State Key Laboratory of Livestock and Poultry Breeding,Guangdong Public Laboratory of Animal Breeding and Nutrition,Guangdong Key Laboratory of Animal Breeding and Nutrition,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China,China;State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-Sen University,Guangzhou 510006,China;Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation,Institute of Animal Husbandry and Veterinary Science,Henan Academy of Agricultural Sciences,Zhengzhou 450002,China
文献出处：
引用格式：
[1]Shufang Cai;Bin Hu;Qi Zhu;Tianqi Duo;Xiaoyu Wang;Xian Tong;Xiaorong Luo;Renqiang Yuan;Yaosheng Chen;Jing Wang;Chenglong Luo;Baosong Xing;Delin Mo-.Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs)[J].生物化学与生物物理学报（英文版）,2022(08):1122-1132
A类：
Langtang,Delving,Lantang,MyoD+,genitors,Pax7+,35dpc
B类：
Notch,signaling,leads,slower,progression,embryonic,myogenic,differentiation,Landrace,than,pigs,into,porcine,myogenesis,key,elucidate,complex,regulation,breed,specific,ferences,growth,performance,meat,production,Increasing,evidence,proves,that,less,show,earlier,but,little,known,about,underlying,mechanisms,this,study,examine,longissimus,dorsi,muscle,LDM,by,immunohistochemistry,confirm,progenitors,increased,LT,fatty,compared,LR,lean,which,results,more,differentiated,myoblasts,days,post,conception,Additionally,isolated,from,greater,capacity,expression,those,Moreover,active,Inhibition,suppresses,increases,thus,promoting,Consistently,process,differentiating,vivo,limbs,accelerated,when,inhibited,These,indicate,facilitates,maintenance,antagonizes,preventing
AB值：
0.408391
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
