典型文献
Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein
文献摘要：
Nucleocapsid(N)protein plays crucial roles in the life cycle of severe acute respiratory syndrome coro-navirus 2(SARS-CoV-2),including the formation of ribonucleoprotein(RNP)complex with the viral RNA.Here we reported the crystal structures of the N-terminal domain(NTD)and C-terminal domain(CTD)of the N protein and an NTD-RNA complex.Our structures reveal a unique tetramer organization of NTD and identify a distinct RNA binding mode in the NTD-RNA complex,which could contribute to the formation of the RNP complex.We also screened small molecule inhibitors of N-NTD and N-CTD and discovered that ceftriaxone sodium,an antibiotic,can block the binding of RNA to NTD and inhibit the formation of the RNP complex.These results together could facilitate the further research of antiviral drug design target-ing N protein.
文献关键词：
中图分类号：
作者姓名：
Xiaodong Luan;Xinming Li;Yufan Li;Gengchen Su;Wanchao Yin;Yi Jiang;Ning Xu;Feng Wang;Wang Cheng;Ye Jin;Leike Zhang;H.Eric Xu;Yi Xue;Shuyang Zhang
作者机构：
School of Medicine,Tsinghua University,Beijing 100084,China;Department of Cardiology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Tsinghua-Peking Center for Life Sciences,Tsinghua University,Beijing 100084,China;School of Life Science,Tsinghua University,Beijing 100084,China;Beijing Advanced Innovation Center for Structural Biology,Beijing 100084,China;The CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;WuxiBiortus Biosciences Co.,Ltd.,Jiangyin 214437,China;State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Xiaodong Luan;Xinming Li;Yufan Li;Gengchen Su;Wanchao Yin;Yi Jiang;Ning Xu;Feng Wang;Wang Cheng;Ye Jin;Leike Zhang;H.Eric Xu;Yi Xue;Shuyang Zhang-.Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein)[J].科学通报（英文版）,2022(22):2327-2335
A类：
ceftriaxone
B类：
Antiviral,drug,design,structural,insights,into,terminal,domain,SARS,CoV,nucleocapsid,Nucleocapsid,plays,crucial,roles,life,cycle,severe,acute,respiratory,syndrome,coro,navirus,including,formation,ribonucleoprotein,RNP,complex,Here,we,reported,crystal,structures,NTD,CTD,Our,reveal,unique,tetramer,organization,identify,distinct,binding,mode,which,could,contribute,We,also,screened,small,molecule,inhibitors,discovered,that,sodium,antibiotic,can,block,These,results,together,facilitate,further,research,antiviral,target
AB值：
0.545595
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
