Antimicrobial resistance(AMR)is unquestionably-one of the most severe,international public health crises that mankind faces now and in the next decades,with the latest data indicating global deaths quintuple over the past five years to claim nearly 5 million lives[1],which seems substantially underestimated the projected health impact(10 million deaths)and economic burden(US$100 trillion)of AMR by 2050[2].To counteract the burgeoning AMR crisis,the One Health initiative has called for international collec-tive effort in improving human,animal and environmental health through integrated management of this interfacial triad.Among which,the environmental dimension is often underrepresented,especially soil compartment as the origin,reservoir and transmis-sion route for propagating antibiotic resistance genes(ARGs)in microbiota that exacerbate AMR[3].Despite a clear correlation between higher antimicrobial exposure to enhanced resistance can be established in the clinical setting,a direct causal dose-re-sponse relationship in the natural environment remains indistinct otherwise.It unveils a potential missing link that has been over-looked between the human-animal-environment interfaces while assessing the roles of antimicrobials in triggering resistance,which is bioavailability.This commentary intends to draw on the unique perspective of this often-secluded element,bioavailability,for environmental surveillance to monitor the partition and fate of bioavailable antimicrobials as well as to identify the threshold con-centration that contributes to the development of resistance.Tak-ing into account the bioavailability factor might be paramount in striking a balance between the necessity of antibiotic applications for safeguarding human health,preventing the growth of AMR and environmental protection.

Han Yeong Kaw;Jing Yu;Xuejing Ma;Bee Geok Yeo;Lizhong Zhu;Wei Wang

Department of Environmental Science,Zhejiang University,Hangzhou 310058,China;Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control,Hangzhou 310058,China;Laboratory of Organic Geochemistry(LOG),Tokyo University of Agriculture and Technology,Fuchu 183-8509,Japan

科学通报（英文版）

[1]Han Yeong Kaw;Jing Yu;Xuejing Ma;Bee Geok Yeo;Lizhong Zhu;Wei Wang-.Environmental bioavailability:a potentially overlooked element in triggering antimicrobial resistance)[J].科学通报（英文版）,2022(22):2269-2271

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