典型文献
Harnessing nature's biosynthetic capacity to facilitate total synthesis
文献摘要：
Natural products(NPs)have long piqued the interests of chemists due to their structural complexity.More importantly,evolution has conferred NPs with the ability to interact with biological macromolecules(such as nucleic acids,proteins,carbohydrates and lipids),making them privileged scaffolds for drug discovery.Until now,＞50％of clinically approved drugs have been derived directly from NPs or their derivatives[1].The difficulty in obtaining sufficient materials from their source organisms has been a major challenge in developing novel medicines from NPs.Although synthetic chemistry has arguably advanced to the point at which organic chemists can synthesize practically all NP types,producing most NPs through total synthesis within a reasonable cost and time range remains difficult.
文献关键词：
中图分类号：
作者姓名：
Haili Zhang;Ge Liao;Xiaozhou Luo;Xiaoyu Tang
作者机构：
Institute of Chemical Biology,Shenzhen Bay Laboratory,China;Center for Synthetic Biochemistry,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,China
文献出处：
引用格式：
[1]Haili Zhang;Ge Liao;Xiaozhou Luo;Xiaoyu Tang-.Harnessing nature's biosynthetic capacity to facilitate total synthesis)[J].国家科学评论（英文版）,2022(11):11-13
A类：
piqued
B类：
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AB值：
0.726358
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