典型文献
Itch perception is reflected by neuronal ignition in the primary somatosensory cortex
文献摘要：
Multiple cortical areas including the primary somatosensory cortex(Si)are activated during itch signal processing,yet cortical representation of itch perception remains unknown.Using novel miniature two-photon microscopic imaging in free-moving mice,we investigated the coding of itch perception in S1.We found that pharmacological inactivation of S1 abolished itch-induced scratching behavior,and the itch-induced scratching behavior could be well predicted by the activity of a fraction of layer 2/3 pyramidal neurons,suggesting that a subpopulation of S1 pyramidal neurons encoded itch perception,as indicated by immediate subsequent scratching behaviors.With a newly established optogenetics-based paradigm that allows precisely controlled pruritic stimulation,we found that a small fraction of S 1 neurons exhibited an ignition-like pattern at the detection threshold of itch perception.Our study revealed the neural mechanism underlying itch perceptual coding in S1,thus paving the way for the study of cortical representation of itch perception at the single-neuron level in freely moving animals.
文献关键词：
中图分类号：
作者姓名：
Xiao-Jun Chen;Yan-He Liu;Ning-Long Xu;Yan-Gang Sun
作者机构：
Institute of Neuroscience,State Key Laboratory of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China
文献出处：
引用格式：
[1]Xiao-Jun Chen;Yan-He Liu;Ning-Long Xu;Yan-Gang Sun-.Itch perception is reflected by neuronal ignition in the primary somatosensory cortex)[J].国家科学评论（英文版）,2022(06):85-94
A类：
Itch
B类：
perception,reflected,by,neuronal,ignition,primary,somatosensory,cortex,Multiple,cortical,areas,including,Si,activated,during,itch,signal,processing,yet,representation,remains,unknown,Using,novel,miniature,two,photon,microscopic,imaging,moving,mice,investigated,coding,S1,We,found,that,pharmacological,inactivation,abolished,induced,scratching,could,well,predicted,activity,fraction,layer,pyramidal,neurons,suggesting,subpopulation,encoded,indicated,immediate,subsequent,behaviors,With,newly,established,optogenetics,paradigm,allows,precisely,controlled,pruritic,stimulation,small,exhibited,like,pattern,detection,threshold,Our,study,revealed,neural,mechanism,underlying,perceptual,thus,paving,way,single,level,freely,animals
AB值：
0.55257
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
