Objective:To systematically evaluate the efficacy and safety of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of digestive ulcer and inflammation Helicobacter pylori-Peptic Ulcer(Hp-PU)caused by Helicobacter pylori(Hp).Methods:Randomized controlled trials(RCTs)of Compound Stomachache Capsule(复方胃痛胶囊)in the treatment of Hp-PU were screened out by searching CNKI,VIP,Wanfang,China Biomedical Literature Service System,Cochrane Library,PubMed,EMbase,Web of Science and ClinicalTrials.gov.Meta-analysis was performed with RevMan 5.4 software.Results:Three RCTs were included,including 331 patients of 166 patients in the experimental group(Compound Stomachache Capsule(复方胃痛胶囊)+conventional western medicine treatment)and 165 patients in the control group(conventional western medicine treatment).Meta-analysis data showed that Hp eradication rate(RR=1.10,95%CI[1.01-1.19],P=0.03)was significantly higher in the experimental group than in the control group.The experimental group was superior to the control group in improving clinical symptoms(RR=1.59,95%CI[1.22-2.06],P=0.0006).Conclusion:According to the current evidence,the Compound Stomachache Capsule(复方胃痛胶囊)combined with conventional Western medicine treatment can improve the Hp eradication rate of Hp-PU,relieve symptoms,and do not increase the incidence of adverse reactions.However,the number of included studies is small and the sample size is small,so its effectiveness and safety need further verification.

LAI Su-yu;XI Jun-yu;LYU Jian;SHI Bu-wen;XIE Yan-ming

Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China

世界中西医结合杂志（英文）

[1]LAI Su-yu;XI Jun-yu;LYU Jian;SHI Bu-wen;XIE Yan-ming-.Meta-analysis on Efficacy and Safety of Compound Stomachache Capsule(复方胃痛胶囊)in Treating Digestive Ulcer and Inflammation Caused by Helicobacter Pylori)[J].世界中西医结合杂志（英文）,2022(06):1-10

Stomachache,+conventional

analysis,Efficacy,Safety,Compound,Capsule,胃痛,Treating,Digestive,Ulcer,Inflammation,Caused,by,Helicobacter,Pylori,Objective,To,systematically,evaluate,efficacy,safety,treatment,digestive,ulcer,inflammation,pylori,Peptic,Hp,PU,caused,Methods,Randomized,controlled,trials,RCTs,were,screened,out,searching,VIP,Wanfang,China,Biomedical,Literature,Service,System,Cochrane,Library,EMbase,ClinicalTrials,gov,was,performed,RevMan,software,Results,Three,included,including,patients,experimental,group,western,medicine,data,showed,that,eradication,rate,RR,significantly,higher,than,superior,improving,clinical,symptoms,Conclusion,According,current,evidence,combined,improve,relieve,not,increase,incidence,adverse,reactions,However,number,studies,small,sample,size,its,effectiveness,need,further,verification

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