Objective: To systematically review the effects of electroacupuncture on neurocognitive dysfunction and inflammatory factors in elderly patients after general anesthesia. Methods: Computer retrieval of EMBASE, The Cochrane Library, PubMed, Web of Science, CBM, CNKI, Wanfang Data, and VIP databases. The time limit was until April 17, 2021. The literature on the effect of electroacupuncture on postoperative neurocognitive dysfunction in elderly patients was searched. Two researchers separately strictly screened and evaluated the included literature, and then analyzed them using RevMan 5.3 software. Results: Electroacupuncture improved the MMSE score on the first [SMD=2.08, 95％CI (1.14, 3.02), P<0.0001] and third days [SMD=0.87, 95％CI (0.15, 1.59), P=0.02] after surgery; the incidence of PNCD on the first [OR=0.37, 95％CI (0.26, 0.54), P<0.00001] and third days [OR=0.37, 95％CI (0.25, 0.56), P<0.00001] after surgery were reduced; IL-6 expression at the end of the operation [SMD=-0.96, 95％CI (-1.88, -0.04), P=0.04] was reduced; accelerated the recovery time from anesthesia [SMD=-1.15, 95％CI (-1.43, -0.87), P<0.00001]; the incidence of postoperative nausea and vomiting [OR=0.39, 95％CI (0.20, 0.78), P=0.007] was reduced. Compared with the control group, the expression of IL-6 on the first [SMD=-0.24, 95％CI (-0.83, 0.36), P=0.43] and second days [SMD=-0.35, 95％CI (-0.93, 0.23), P=0.24] after operation, and the expression of TNF-α at the end of operation [SMD=-0.65, 95％CI (-1.33, 0.03), P=0.06] and the first day [SMD=-0.51, 95％CI (-1.02, -0.01), P=0.05] after operation had no statistically significant difference. Conclusion: Electroacupuncture can effectively reduce the incidence of postoperative neurocognitive dysfunction and postoperative nausea and vomiting in elderly patients, and accelerate the recovery time from anesthesia. The difference in the frequency and duration of electroacupuncture may potentially affect clinical efficacy.

QIN Xiao-yu;ZHANG Jie;DING Sheng-shuang;DUAN Rong-rong;HUANG Wei-hua;LU Xiao-ting;WANG Chun-ai

The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Anesthesiology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China

世界中西医结合杂志（英文）

[1]QIN Xiao-yu;ZHANG Jie;DING Sheng-shuang;DUAN Rong-rong;HUANG Wei-hua;LU Xiao-ting;WANG Chun-ai-.Effects of Electroacupuncture Combined with General Anesthesia on Postoperative Neurocognitive Dysfunction and Inflammatory Factors in Elderly Patients: a Meta-analysis)[J].世界中西医结合杂志（英文）,2022(01):19-28

PNCD

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