典型文献
Syntheses,Crystal Structures,Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone
文献摘要：
Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C6H5(O)C=N-N=C(Ph)CH(Ph)O]2[(n-Bu)2Sn]2 and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C6H4(O)C=N-N=C(Ph)CH(Ph)O]2[(n-Bu)2Sn]2 were synthesized and characterized by IR,1H,13C and 119Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complexⅠ belongs to monoclinic system,space group P21/n with a =11.1942(8),b =10.4754(7),c =23.6700(17) (A),β =101.529(2)°,Z =2,V=2719.6(3) (A)3,Dc =1.371 Mg·m-3,μ(MoKα) =0.966 mm-1,F(000) =1152,R =0.0458 and wR =0.1312.The crystal of complex Ⅱ is of triclinic system,space group P(-1) with a =9.9960(4),b =11.2466(4),c =14.0509(5) (A),α =69.4190(10)°,β=70.0600(10)°,γ =81.8090(10)°,Z =1,V=1389.69(9) (A)3,Dc =1.380 Mg·m-3,μ(MoKα) =0.950 mm-1,F(000) =592,R =0.0284 and wR =0.0690.In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines (MCF7,NCI-H460 and HepG2),and complex Ⅱ exhibited better antitumor activity than Ⅰ.The interaction between complexes and calf thymus DNA was studied by UV-vis,fluorescence spectroscopy and viscosity measurements.
文献关键词：
中图分类号：
作者姓名：
JIANG Wu-Jiu;TAN Yu-Jun;MAN Jia-Tai;TAN Yu-Xing
作者机构：
Key Laboratory of Functional Metal-organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials,University of Hunan Province,Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of XiangJiang River,College of Chemistry and Materials Science,Hengyang Normal University,Hengyang,Hunan 421008,China;Emergency Department,Xiangya Hospital,Central South University,Changsha 410008,China
文献出处：
引用格式：
[1]JIANG Wu-Jiu;TAN Yu-Jun;MAN Jia-Tai;TAN Yu-Xing-.Syntheses,Crystal Structures,Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone)[J].结构化学,2022(02):105-113
A类：
Syntheses,Dibutyltin,Benzoin,Aroyl,Hydrazone,benzoin,salicyl
B类：
Crystal,Structures,Anticancer,Activities,Binding,Properties,Complexes,Based,benzoyl,hydrazone,C6H5,Ph,CH,Bu,2Sn,dibutyltin,C6H4,were,synthesized,characterized,by,1H,13C,119Sn,NMR,spectra,HRMS,elemental,analysis,thermal,stability,crystal,structures,determined,ray,diffraction,belongs,monoclinic,system,space,group,P21,Dc,Mg,MoK,wR,triclinic,In,vitro,antitumor,activities,both,complexes,evaluated,CCK8,method,against,three,human,cell,lines,MCF7,NCI,H460,HepG2,exhibited,better,activity,than,interaction,between,calf,thymus,was,studied,UV,fluorescence,spectroscopy,viscosity,measurements
AB值：
0.579921
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