典型文献
Structural and Functional Analyses of Hub MicroRNAs in An Integrated Gene Regulatory Network of Arabidopsis
文献摘要：
MicroRNAs(miRNAs)are trans-acting small regulatory RNAs that work coordinately with transcription factors(TFs)to shape the repertoire of cellular mRNAs available for translation.Despite our growing knowledge of individual plant miRNAs,their global roles in gene regulatory networks remain mostly unassessed.Based on interactions obtained from public databases and curated from the literature,we reconstructed an integrated miRNA network in Arabidopsis that includes 66 core TFs,318 miRNAs,and 1712 downstream genes.We found that miRNAs occupy distinct niches and enrich miRNA-containing feed-forward loops(FFLs),particularly those with miRNAs as intermediate nodes.Further analyses revealed that miRNA-containing FFLs coordi-nate TFs located in different hierarchical layers and that intertwined miRNA-containing FFLs are associated with party and date miRNA hubs.Using the date hub MIR858A as an example,we performed detailed molecular and genetic analyses of three interconnected miRNA-containing FFLs.These analyses revealed individual functions of the selected miRNA-containing FFLs and elucidated how the date hub miRNA fulfills multiple regulatory roles.Collectively,our findings highlight the prevalence and importance of miRNA-containing FFLs,and provide new insights into the design principles and control logics of miRNA regulatory networks governing gene expression programs in plants.
文献关键词：
中图分类号：
作者姓名：
Zhaoxu Gao;Jun Li;Li Li;Yanzhi Yang;Jian Li;Chunxiang Fu;Danmeng Zhu;Hang He;Huaqing Cai;Lei Li
作者机构：
State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences,and School of Advanced Agricultural Sciences,Peking University,Beijing 100871,China;Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China;CAS Key Laboratory of Biofuels,Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China;National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China
文献出处：
引用格式：
[1]Zhaoxu Gao;Jun Li;Li Li;Yanzhi Yang;Jian Li;Chunxiang Fu;Danmeng Zhu;Hang He;Huaqing Cai;Lei Li-.Structural and Functional Analyses of Hub MicroRNAs in An Integrated Gene Regulatory Network of Arabidopsis)[J].基因组蛋白质组与生物信息学报（英文版）,2022(04):747-764
A类：
unassessed,FFLs,MIR858A,logics
B类：
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AB值：
0.558719
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